Development of pectin nanoparticles through mechanical homogenization for dissolution enhancement of itraconazole

• Published in: Asian journal of pharmceutical sciences Vol. 11; no. 3; pp. 365 - 375
• Main Authors: Burapapadh, Kanokporn, Takeuchi, Hirofumi, Sriamornsak, Pornsak
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2016; Elsevier
• Subjects: Itraconazole; Nanoparticles; Pectin; Poorly water-soluble drug; Stability; Poorly water-soluble drug; Nanoparticles; Pectin; Stability; Itraconazole
• ISSN: 1818-0876; 2221-285X
• DOI: 10.1016/j.ajps.2015.07.003

A simple method to fabricate itraconazole (ITZ)-loaded pectin nanoparticles prepared from nanoemulsion templates is described in this study. Nanoemulsions containing ITZ were prepared by a mechanical homogenization using pectin as emulsifier. After freeze-drying, the morphology, crystallinity state, thermal properties, drug dissolution and stability of the obtained pectin nanoparticles were characterized. The results demonstrated that the morphology of freeze-dried products was different, depending on the type of internal phase; the nanoparticles prepared from chloroform-based nanoemulsions were completely dried and provided a fragile characteristic. The pectin nanoparticles also demonstrated good properties in terms of redispersibility, thermal properties, drug crystallinity and dissolution. The ITZ-loaded pectin nanoparticles showed high percentage of drug dissolved (about 60–80% within 2 h), and maintained their good dissolution properties even after 1-year storage. The results suggested that freeze-dried pectin nanoparticles prepared from nanoemulsions could be used as an effective carrier for enhancement of ITZ dissolution.