Teratogenic effects of benzo[a]pyrene in developing chick embryo

The effect of benzo[a]pyrene (BP), an established carcinogen, on developing chick embryos was investigated. The embryos were exposed in different stages of development to various doses of BP via the yolk sac route. This resulted in retarded growth, as reflected by lower embryonic body weight, reduce...

Full description

Saved in:
Bibliographic Details
Published inToxicology letters Vol. 40; no. 3; pp. 195 - 201
Main Authors Anwer, J, Mehrotra, N.K
Format Journal Article
LanguageEnglish
Published Netherlands 01.03.1988
Subjects
Abnormalities, Drug-Induced - etiology
Animals
Benzo(a)pyrene - toxicity
benzopyrene
Bone and Bones - abnormalities
Chick Embryo
chicks
Dose-Response Relationship, Drug
embryo (animal)
teratogens
Online AccessGet more information

Cover

More Information
Summary:The effect of benzo[a]pyrene (BP), an established carcinogen, on developing chick embryos was investigated. The embryos were exposed in different stages of development to various doses of BP via the yolk sac route. This resulted in retarded growth, as reflected by lower embryonic body weight, reduced crown-rump length and bill length. Abnormal survivors showed remarkably twisted legs with shortening of the bones, abdominal oedema, haematomas, blisters and a short neck. These findings suggest that BP is a teratogen when injected via this route, and the 'oedema syndrome' is a possible mechanism causing teratogenic effects in developing chick embryos when treated with BP.
ISSN:0378-4274
1879-3169
DOI:10.1016/0378-4274(88)90041-0