Evidence of nerve sheath differentiation and high grade morphology in sclerosing epithelioid fibrosarcoma

• Published in: Journal of clinical pathology Vol. 54; no. 9; pp. 721 - 723
• Main Authors: Hanson, I M, Pearson, J M, Eyden, B P, Slawik, S, Harris, M
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.09.2001; BMJ; BMJ Publishing Group LTD
• Subjects: Abdomen; Biological and medical sciences; Cell Differentiation; Cytoplasm; Fatal Outcome; Fibrosarcoma; Fibrosarcoma - secondary; Fibrosarcoma - ultrastructure; Follow-Up Studies; Gastroenterology. Liver. Pancreas. Abdomen; high grade morphology; Humans; Lumbar Vertebrae; Male; Medical sciences; Metastasis; Microscopy; Middle Aged; Morphology; nerve sheath differentiation; Proteins; Retroperitoneal Neoplasms - ultrastructure; Sarcoma; sclerosing epithelioid fibrosarcoma; Short Report; Spinal Neoplasms - secondary; Tumors; Human; Immunohistochemistry; Sarcoma; Process variant; Fibrosarcoma; Male; Malignant tumor; Cell differentiation; Electron microscopy; Sheath; Sclerosis; Abdomen; Case study; Nerve; Pathology; Abdominal disease; Epithelioid cell; Adult; High malignancy
• ISSN: 0021-9746; 1472-4146
• DOI: 10.1136/jcp.54.9.721

Sclerosing epithelioid fibrosarcoma is a recently described sarcoma in which ultrastructural evidence of fibroblastic differentiation forms part of the diagnostic criteria. This report describes a further case of this tumour, which showed evidence of both fibroblastic and perineurial differentiation by immunohistochemistry and electron microscopy, and which had areas of high grade morphology. The tumour metastasised and the patient died of disease 12 months after presentation. The relevance of these findings to diagnosis and differentiation in these tumours is discussed.