Change in Albuminuria Is Predictive of Cardiovascular Outcome in Normotensive Patients With Type 2 Diabetes and Microalbuminuria

• Published in: Diabetes care Vol. 30; no. 12; pp. 3119 - 3121
• Main Authors: Zandbergen, Adrienne A.M, Vogt, Liffert, de Zeeuw, Dick, Lamberts, Steven W.J, Ouwendijk, Rob J.T.H, Baggen, Marinus G.A, Bootsma, Aart H
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.12.2007
• Subjects: Albuminuria; Albuminuria - complications; Albuminuria - metabolism; Associated diseases and complications; Biological and medical sciences; Blood Pressure; Cardiovascular disease; Cardiovascular diseases; Care and treatment; Changes; Cholesterol, HDL - blood; Cohort Studies; Complications and side effects; Diabetes; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - urine; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - epidemiology; Diabetics; Diagnosis; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Follow-Up Studies; Health aspects; Hospitals; Humans; Male; Medical sciences; Metabolic diseases; Miscellaneous; Mortality; Multivariate Analysis; Netherlands - epidemiology; Predictive Value of Tests; Prospective Studies; Public health. Hygiene; Public health. Hygiene-occupational medicine; Regression Analysis; Risk factors; Sample size; Studies; Time Factors; Netherlands; United States; Endocrinopathy; Kidney disease; Type 2 diabetes; Human; Urine; Urinary system disease; Prognosis; Nutrition; Albumin; Patient; Metabolic diseases; Change; Concomitant disease; Evolution; Diabetic nephropathy; Circulatory system; Predictive factor; Endocrinology; Microalbuminuria; Proteinuria
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc07-0960

To our knowledge, our study is the first demonstrating that, even with no appreciable changes or even rises in blood pressure, change in albuminuria differentiates the cardiovascular outcome in type 2 diabetic patients without hypertension.