Nutmeg oil: identification and quantitation of its most active constituents as inhibitors of platelet aggregation

Three distilled or commercially available nutmeg oils were analysed and their chemical composition compared with their capacity to inhibit platelet aggregation in vitro. It could be clearly shown that eugenol and isoeugenol play the major role in the detected activity of nutmeg. Medicinally, it appe...

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Bibliographic Details
Published inJournal of ethnopharmacology Vol. 29; no. 2; pp. 179 - 188
Main Authors Janssens, J, Laekeman, G.M, Pieters, L.A.C, Totte, J, Herman, A.G, Vlietinck, A.J
Format Journal Article
LanguageEnglish
Published Ireland 01.05.1990
Subjects
aggregation
Animals
Arachidonic Acid
Arachidonic Acids - pharmacology
blood platelets
Chromatography, Gas
Chromatography, Thin Layer
Condiments - analysis
Eugenol - analogs & derivatives
Eugenol - analysis
In Vitro Techniques
Myristica fragrans
nutmegs
oils
Plant Oils - analysis
Plant Oils - pharmacology
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors
Rabbits
traditional medicine
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Summary:Three distilled or commercially available nutmeg oils were analysed and their chemical composition compared with their capacity to inhibit platelet aggregation in vitro. It could be clearly shown that eugenol and isoeugenol play the major role in the detected activity of nutmeg. Medicinally, it appears that nutmeg oil and nutmeg powder can be replaced by eugenol and/or isoeugenol.
ISSN:0378-8741
1872-7573
DOI:10.1016/0378-8741(90)90054-W