The influence of organ acceptance criteria on long-term graft survival: outcomes of a kidney transplant program

• Published in: The American journal of surgery Vol. 195; no. 2; pp. 149 - 152
• Main Authors: Foster, Clarence E., M.D, Weng, Renee R., Pharm.D, Smith, Craig V., M.D, Imagawa, David K., M.D., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2008; Elsevier; Elsevier Limited
• Subjects: Acceptance criteria; Acceptance rate; Adolescent; Adult; Age; Biological and medical sciences; Cadaver; Donations; Donor Selection; Failure; Female; Follow-Up Studies; General aspects; Graft Rejection; Graft Survival; Humans; Kidney transplant; Kidney transplant outcomes; Kidney transplantation; Kidney Transplantation - methods; Kidney Transplantation - statistics & numerical data; Kidneys; Male; Medical sciences; Middle Aged; Organ acceptance; Organ acceptance criteria; Organ acceptance rate; Organ criteria; Patients; Pediatrics; Probability; Program Evaluation; Registries; Retrospective Studies; Risk Assessment; Statistics, Nonparametric; Success; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Tissue and Organ Procurement - organization & administration; Tissue Donors; Transplant rate; Treatment Outcome; Organ acceptance rate; Kidney transplant; Acceptance rate; Organ acceptance criteria; Kidney transplant outcomes; Acceptance criteria; Transplant rate; Kidney transplantation; Organ acceptance; Organ criteria; Acceptance; Program; Prognosis; Rate; Long term; Survival; Kidney; Medicine; Treatment; Criterion; Surgery; Evolution; Graft; Organ
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/j.amjsurg.2007.11.003

Abstract Background In an effort to improve our transplant program’s dead-donor kidney acceptance criteria, we compared 2 different consecutive time periods in our transplant program. Period I, in which the program used more-restrictive criteria in accepting dead-donor kidneys for our patients, and period II, when the program used less-restrictive criteria for the dead-donor kidneys that were accepted. The less-restrictive criteria resulted in an increase in the number of renal transplants performed. Methods A retrospective database analysis was performed of all organ-donor offers to a single kidney transplant program from July 1, 2004, to September 30, 2006 (period I = July 1, 2004, through July 10, 2005, and period II = July 11, 2005 through September 30, 2006). Kidney acceptance rates were compared between 2 consecutive time periods during which the program used different organ acceptance criteria. Data analysis included a comparison of donor characteristics, reason for organ refusal, creatinine clearance, and graft survival. Graft survival was obtained for both kidneys associated with each offer, even if 1 or both of the organs were transplanted at a different center. Results Donor age and kidney quality were the most common reasons for refusal during both transplant periods. The organ acceptance rate improved markedly during period II. There was a marked increase in the number of kidney transplants performed during a 12-month period when comparing the 2 periods: 16 transplants during period I versus 46 transplants during period II. Graft survival was not significantly different between the 2 periods. Calculated creatinine clearance, which we used as a marker of organ quality, was statistically lower during period II. Conclusions Increased acceptance rate was not associated with statistically significant decreased graft survival. Although an increase in delayed graft function was associated with broader acceptance criteria, this factor did not affect overall graft survival. By increasing our kidney acceptance rate, we were able to successfully transplant more patients.