A Cytokine in the Drosophila Stress Response

The fruit fly, Drosophila melanogaster, has become a popular tool for studying immediate reactions to environmental hazards, such as the heat shock and innate immune responses. In mammals, protective responses to infections and other insults are coordinated by a complex network of cytokines that med...

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Bibliographic Details
Published inDevelopmental Cell Vol. 5; no. 3; pp. 360 - 361
Main Authors Hultmark, Dan, Ekengren, Sophia
Format Book Review Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2003
Subjects
Animals
Cytokines - physiology
Drosophila melanogaster
Drosophila melanogaster - physiology
Gene Expression Regulation
Heat-Shock Proteins - physiology
Heat-Shock Response - physiology
Immunity, Innate - physiology
Signal Transduction - genetics
Signal Transduction - physiology
Signal Transduction/genetics/physiology
Stress, Physiological - metabolism
Stress/metabolism
Immunity
Natural/physiology
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Summary:The fruit fly, Drosophila melanogaster, has become a popular tool for studying immediate reactions to environmental hazards, such as the heat shock and innate immune responses. In mammals, protective responses to infections and other insults are coordinated by a complex network of cytokines that mediate cell-to-cell signaling. By contrast, the corresponding heat shock and innate immune responses in Drosophila have usually been regarded as cell-autonomous processes. However, in this issue of Developmental Cell, Agaisse et al. (2003) show that cytokines do play a role in mediating an acute phase response in this organism.
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ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(03)00268-5