Cell type ontologies of the Human Cell Atlas

Massive single-cell profiling efforts have accelerated our discovery of the cellular composition of the human body while at the same time raising the need to formalize this new knowledge. Here, we discuss current efforts to harmonize and integrate different sources of annotations of cell types and s...

Full description

Saved in:
Bibliographic Details
Published inNature cell biology Vol. 23; no. 11; pp. 1129 - 1135
Main Authors Osumi-Sutherland, David, Xu, Chuan, Keays, Maria, Levine, Adam P, Kharchenko, Peter V, Regev, Aviv, Lein, Ed, Teichmann, Sarah A
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.11.2021
Subjects
Annotations
Atlases as Topic
Biological Ontologies
Biological research
Biology, Experimental
Biomarkers - metabolism
Cell Biology
Cell Lineage
Cells - classification
Cells - metabolism
Cells - pathology
Controlled vocabularies
Data Mining
Disease
Gene Ontology
Genomics
High-Throughput Nucleotide Sequencing
Humans
Ontology
Phenotype
Single-Cell Analysis
Systems Integration
Transcriptome
United Kingdom
Online AccessGet full text

Cover

More Information
Summary:Massive single-cell profiling efforts have accelerated our discovery of the cellular composition of the human body while at the same time raising the need to formalize this new knowledge. Here, we discuss current efforts to harmonize and integrate different sources of annotations of cell types and states into a reference cell ontology. We illustrate with examples how a unified ontology can consolidate and advance our understanding of cell types across scientific communities and biological domains.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-021-00787-7