Visceral involvements and long-term sequelae in drug-induced hypersensitivity syndrome

• Published in: The Medical clinics of North America Vol. 94; no. 4; p. 743
• Main Authors: Kano, Yoko, Ishida, Tadashi, Hirahara, Kazuhisa, Shiohara, Tetsuo
• Format: Journal Article
• Language: English
• Published: United States 01.07.2010
• Subjects: Autoimmune Diseases - chemically induced; Chemical and Drug Induced Liver Injury - diagnosis; Chemical and Drug Induced Liver Injury - etiology; Diabetes Mellitus, Type 1 - chemically induced; Digestive System Diseases - chemically induced; Digestive System Diseases - etiology; Drug Hypersensitivity - complications; Drug Hypersensitivity - diagnosis; Heart Diseases - chemically induced; Herpesviridae - physiology; Herpesviridae Infections - chemically induced; Herpesviridae Infections - virology; Kidney Diseases - chemically induced; Lung Diseases - chemically induced; Lupus Erythematosus, Systemic - chemically induced; Meningoencephalitis - chemically induced; Multiple Organ Failure - chemically induced; Multiple Organ Failure - virology; Risk Factors; Scleroderma, Systemic - chemically induced; Syndrome; Thyroiditis - chemically induced; Time Factors; Virus Activation
• ISSN: 1557-9859
• DOI: 10.1016/j.mcna.2010.03.004

Drug-induced hypersensitivity syndrome (DIHS) is a severe systemic reaction with several herpesvirus reactivations. Multiple organ failures appear during the course of the disease. The severity of DIHS is determined by the degree of visceral involvement. Autoimmune diseases also develop several months to years after the apparent clinical resolution of DIHS.