Current Positioning against Severe Infections Due to Klebsiella pneumoniae in Hospitalized Adults

Infections due to Klebsiella pneumoniae have been increasing in intensive care units (ICUs) in the last decade. Such infections pose a serious problem, especially when antimicrobial resistance is present. We created a task force of experts, including specialists in intensive care medicine, anaesthes...

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Published inAntibiotics (Basel) Vol. 11; no. 9; p. 1160
Main Authors Vidal-Cortés, Pablo, Martin-Loeches, Ignacio, Rodríguez, Alejandro, Bou, Germán, Cantón, Rafael, Diaz, Emili, De la Fuente, Carmen, Torre-Cisneros, Julián, Nuvials, Francisco Xavier, Salavert, Miguel, Aguilar, Gerardo, Nieto, Mercedes, Ramírez, Paula, Borges, Marcio, Soriano, Cruz, Ferrer, Ricard, Maseda, Emilio, Zaragoza, Rafael
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 27.08.2022
MDPI
Subjects
Algorithms
Anesthesia
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Carbapenemase
carbapenemase-producing Enterobacterales (CPE)
ceftazidime-avibactam
Cloning
Drug resistance
Enzymes
Epidemiology
Genes
Health risks
Hospitals
Infections
Infectious diseases
Intensive care units
Klebsiella
Klebsiella pneumoniae
KPC
Microbiology
Mutation
Nosocomial infection
nosocomial pneumonia
Pathogens
Permeability
Phylogenetics
Plasmids
Priorities
Review
VAP
Italy
United States > US
China
Spain
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Summary:Infections due to Klebsiella pneumoniae have been increasing in intensive care units (ICUs) in the last decade. Such infections pose a serious problem, especially when antimicrobial resistance is present. We created a task force of experts, including specialists in intensive care medicine, anaesthesia, microbiology and infectious diseases, selected on the basis of their varied experience in the field of nosocomial infections, who conducted a comprehensive review of the recently published literature on the management of carbapenemase-producing Enterobacterales (CPE) infections in the intensive care setting from 2012 to 2022 to summarize the best available treatment. The group established priorities regarding management, based on both the risk of developing infections caused by K. pneumoniae and the risk of poor outcome. Moreover, we reviewed and updated the most important clinical entities and the new antibiotic treatments recently developed. After analysis of the priorities outlined, this group of experts established a series of recommendations and designed a management algorithm.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11091160