Processes of Homeostatic Proliferation in the Pathogenesis of Autoimmune Glomerulonephritis Induced by Chronic Graft-Versus-Host Reaction

• Published in: Bulletin of experimental biology and medicine Vol. 149; no. 1; pp. 54 - 56
• Main Authors: Goiman, E. V, Kudaeva, O. T, Ilyina, N. A, Borisov, V. I, Kozhevnikov, V. S, Kolesnikova, O. P, Kozlov, V. A
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.07.2010; Springer US; Springer; Springer Nature B.V
• Subjects: Animals; Autoimmune Diseases - etiology; Autoimmune Diseases - physiopathology; Biomedical and Life Sciences; Biomedicine; CD4⁺ and CD8⁺ subpopulations; Cell Biology; Cell Proliferation; chronic graftversus-host reaction; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Glomerulonephritis; Glomerulonephritis - etiology; Glomerulonephritis - physiopathology; Graft vs Host Disease - complications; homeostatic proliferation; IL-7; Immunologic Memory - immunology; Immunology and Microbiology; Interleukin-7 - blood; Internal Medicine; Laboratory Medicine; Lupus; Memory (Computers); Mice; Mice, Inbred DBA; Pathology; Spleen - cytology; Spleen - immunology; T cells; T-Lymphocyte Subsets - immunology; CD4; and CD8; subpopulations; chronic graftversus-host reaction; homeostatic proliferation; IL-7
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-010-0874-7

Lymphopenia developing at the early stage of chronic graft-versus-host reaction is associated with increased content of IL-7 in the peripheral blood and leads to an increase of the CD4⁺ and CD8⁺ cell subpopulations in the spleen of the recipient. After 3 months, some animals develop autoimmune glomerulonephritis (lupus recipients). High levels of IL-7 and T-cells with the memory cell phenotype (CD4⁺CD45RBlow and CD8⁺CD45RBlow) persist in these animals, in contrast to nonlupus recipients without signs of autoimmune disease. This can attest to the involvement of homeostatic proliferation processes in the formation of autoimmune disease in this model.