Splice and Dice: Intronic microRNAs, Splicing and Cancer

Introns span only a quarter of the human genome, yet they host around 60% of all known microRNAs. Emerging evidence indicates the adaptive advantage of microRNAs residing within introns is attributed to their complex co-regulation with transcription and alternative splicing of their host genes. Intr...

Full description

Saved in:
Bibliographic Details
Published inBiomedicines Vol. 9; no. 9; p. 1268
Main Authors Wong, Alex C. H., Rasko, John E. J.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 19.09.2021
MDPI
Subjects
Alternative splicing
Biosynthesis
Cancer
Gene expression
Gene regulation
Genetic engineering
Genomes
Introns
Microprocessors
microRNA
MicroRNAs
miRNA
mirtrons
Proteins
Review
RNA polymerase
splicing factors
Transcription
Online AccessGet full text

Cover

More Information
Summary:Introns span only a quarter of the human genome, yet they host around 60% of all known microRNAs. Emerging evidence indicates the adaptive advantage of microRNAs residing within introns is attributed to their complex co-regulation with transcription and alternative splicing of their host genes. Intronic microRNAs are often co-expressed with their host genes, thereby providing functional synergism or antagonism that is exploited or decoupled in cancer. Additionally, intronic microRNA biogenesis and the alternative splicing of host transcript are co-regulated and intertwined. The importance of intronic microRNAs is under-recognized in relation to the pathogenesis of cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines9091268