In Vitro and In Vivo Antimicrobial Activity of the Novel Peptide OMN6 against Multidrug-Resistant Acinetobacter baumannii

The rapid worldwide spread of antimicrobial resistance highlights the significant need for the development of innovative treatments to fight multidrug-resistant bacteria. This study describes the potent antimicrobial activity of the novel peptide OMN6 against a wide array of drug-resistant Acinetoba...

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Published inAntibiotics (Basel) Vol. 11; no. 9; p. 1201
Main Authors Michaeli, Janna, Mandel, Shira, Maximov, Shelly, Zazoun, Jonathan, Savoia, Paola, Kothari, Nimmi, Valmont, Thomas, Ferrari, Livia, Duncan, Leonard R., Hawser, Stephen, Cohen-Kutner, Moshe, Bachnoff, Niv
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 05.09.2022
MDPI
Subjects
Acinetobacter baumannii
AMR
Animal models
Antibiotics
Antimicrobial activity
Antimicrobial agents
antimicrobial peptides
Antimicrobial resistance
Bacteria
Bacterial infections
Clinical isolates
Drug dosages
Drug resistance
Infections
infectious diseases
Lungs
Multidrug resistance
OMN6
Pathogens
Peptides
Surfactants
United States > US
Italy
Europe
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Summary:The rapid worldwide spread of antimicrobial resistance highlights the significant need for the development of innovative treatments to fight multidrug-resistant bacteria. This study describes the potent antimicrobial activity of the novel peptide OMN6 against a wide array of drug-resistant Acinetobacter baumannii clinical isolates. OMN6 prevented the growth of all tested isolates, regardless of any pre-existing resistance mechanisms. Moreover, in vitro serial-passaging studies demonstrated that no resistance developed against OMN6. Importantly, OMN6 was highly efficacious in treating animal models of lung and blood infections caused by multidrug-resistant A. baumannii. Taken together, these results point to OMN6 as a novel antimicrobial agent with the potential to treat life-threatening infections caused by multidrug-resistant A. baumannii avoiding resistance.
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ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11091201