The independent and combined effects of aerobic exercise and dietary fish intake on serum lipids and glycemic control in NIDDM: a randomized controlled study

• Published in: Diabetes care Vol. 20; no. 6; pp. 913 - 921
• Main Authors: Dunstan, D.W, Mori, T.A, Puddey, I.B, Beilin, L.J, Burke, V, Morton, A.R, Stanton, K.G
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.1997
• Subjects: ACTIVIDAD FISICA; ACTIVITE PHYSIQUE; Adult; Aged; Animals; AZUCAR EN SANGRE; Biological and medical sciences; blood; blood glucose; Blood Glucose - metabolism; Blood Pressure; BLOOD SERUM; BLOOD SUGAR; Body Weight; Cholesterol; Cholesterol - blood; Cholesterol, HDL; Cholesterol, HDL - blood; Cholesterol, LDL; Cholesterol, LDL - blood; DIABETE; DIABETES; Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - therapy; Diabetes. Impaired glucose tolerance; Diet, Diabetic; DIETA TERAPEUTICA; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Exercise; Female; FISH; Fishes; FOOD INTAKE; Humans; INGESTION DE ALIMENTOS; Insulin; Insulin - blood; LIPIDE; LIPIDOS; LIPIDS; Lipids - blood; LOW FAT DIETS; Male; Management. Various non-drug treatments. Langerhans islet grafts; Meat; Medical sciences; metabolism; Middle Aged; Oxygen Consumption; PESCADO; PHYSICAL ACTIVITY; Physical Fitness; physiopathology; POISSON (ALIMENT); PRISE ALIMENTAIRE (HOMME); REGIME ALIMENTAIRE THERAPEUTIQUE; SERUM SANGUIN; SUCRE DU SANG; SUERO SANGUINEO; THERAPEUTIC DIETS; therapy; Triglycerides; Triglycerides - blood; Endocrinopathy; Physical exercise; Human; Edible fish; Check; Cardiovascular disease; Supplemented diet; Non insulin dependent diabetes; Prevention; Vertebrata; Lipemia; Diet therapy; Pisces; Biological effect; Glycemia
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.20.6.913

The independent and combined effects of aerobic exercise and dietary fish intake on serum lipids and glycemic control in NIDDM. A randomized controlled study. D W Dunstan , T A Mori , I B Puddey , L J Beilin , V Burke , A R Morton and K G Stanton Department of Medicine, Royal Perth Hospital, University of Western Australia, Australia. ddunstan@cyllene.uwa.edu.au Abstract OBJECTIVE: The triglyceride-lowering effects of omega-3 fats and HDL cholesterol-raising effects of exercise may be appropriate management for dyslipidemia in NIDDM. However, fish oil may impair glycemic control in NIDDM. The present study examined the effects of moderate aerobic exercise and the incorporation of fish into a low-fat (30% total energy) diet on serum lipids and glycemic control in dyslipidemic NIDDM patients. RESEARCH DESIGN AND METHODS: In a controlled, 8-week intervention, 55 sedentary NIDDM subjects with serum triglycerides > 1.8 mmol/l and/or HDL cholesterol < 1.0 mmol/l were randomly assigned to a low-fat diet (30% daily energy intake) with or without one fish meal daily (3.6 g omega-3/day) and further randomized to a moderate (55-65% VO2max) or light (heart rate < 100 bpm) exercise program. An oral glucose tolerance test (75 g), fasting serum glucose, insulin, lipids, and GHb were measured before and after intervention. Self-monitoring of blood glucose was performed throughout. RESULTS: In the 49 subjects who completed the study, moderate exercise improved aerobic fitness (VO2max) by 12% (from 1.87 to 2.07 l/min, P = 0.0001). Fish consumption reduced triglycerides (0.80 mmol/l, P = 0.03) and HDL3 cholesterol (0.05 mmol/l, P = 0.02) and increased HDL2 cholesterol (0.06 mmol/l, P = 0.01). After adjustment for age, sex, and changes in body weight, fish diets were associated with increases in GHb (0.50%, P = 0.05) and self-monitored glucose (0.57 mmol/l, P = 0.0002), which were prevented by moderate exercise. CONCLUSIONS: A reduced fat diet incorporating one daily fish meal reduces serum triglycerides and increases HDL2 cholesterol in dyslipidemic NIDDM patients. Associated deterioration in glycemic control can be prevented by a concomitant program of moderate exercise.