Analysis of Clinical Characteristics of 556 Spinal Tuberculosis Patients in Two Tertiary Teaching Hospitals in Guangxi Province

• Published in: BioMed research international Vol. 2021; pp. 1344496 - 11
• Main Authors: Zeng, Hao, Liang, Yingfang, He, Jiaguo, Chen, Liyi, Su, Haixia, Liao, Simi, Huang, Sichun, Qin, Hongyu
• Format: Journal Article
• Language: English
• Published: United States Hindawi 10.12.2021; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Abscess - drug therapy; Abscess - pathology; Abscesses; Adolescent; Adult; Antitubercular Agents - therapeutic use; Back pain; Biomedical research; Bone Diseases - drug therapy; Bone Diseases - epidemiology; Chemotherapy; China - epidemiology; Complications and side effects; Correlation analysis; Demographic aspects; Diabetes; Diabetes mellitus; Diagnosis; Disease; Epidemiology; Female; Gender; Health services; Hepatitis B; Hospitals; Hospitals, Teaching; Humans; Hypertension; Low back pain; Low Back Pain - drug therapy; Low Back Pain - epidemiology; Low Back Pain - pathology; Lumbar Vertebrae - pathology; Lumbosacral Region - pathology; Male; Medical prognosis; Medical records; Middle Aged; Neurological complications; Pain; Patients; Pre-eclampsia; Public health; Retrospective Studies; Risk factors; Rural areas; Rural communities; Rural populations; Spinal diseases; Spine; Spine (lumbar); Spine (thoracic); Teaching hospitals; Tertiary Care Centers; Tuberculosis; Tuberculosis, Spinal - epidemiology; Tuberculosis, Spinal - pathology; Vertebrae; Young Adult; China
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2021/1344496

Spinal tuberculosis (STB), which accounts for half of musculoskeletal tuberculosis, is among the leading causes of extrapulmonary tuberculosis. Guangxi Province, located in southern China, is among the most severely affected provinces in China. In this study, we collected and analyzed data from 2 Class-A tertiary teaching hospitals in Nanning City, Guangxi Province, from 2011 to 2019, with the aim of providing reference points for the prevention, diagnosis, treatment, and prognosis analysis of STB, using the epidemiological characteristics of 556 STB cases. Our results revealed that males had a slightly higher incidence (50.17%) compared to females (49.83%), with 64.93% of cases falling between the ages of 18 and 45 years. Cases from rural communities accounted for 63.49% of the reviewed cases. The average time between onset of symptoms and hospitalization was 18.0 months (range: 1 day-220 months). The most commonly reported symptoms were lower back pain (78.60%), radicular pain (51.98%), and systemic toxemia (43.53%). Additionally, 53.98% of the reviewed cases had varying degrees of neurological impairment. The main pathological lesion locations were the lumbar spine (43.53%) and thoracic spine (32.55%). Among them, 72.66% of cases involved at least 2 vertebral segments, and 62.77% of cases presented with paravertebral abscesses. Among the cases reviewed, 90.65% underwent antituberculosis chemotherapy prior to surgery. Following treatment, the cure rate was 78.41%, while 3.78% of patients had postoperative relapse. There were cases of concomitant illnesses among the cases reviewed, 40.65% of patients also had pulmonary tuberculosis, 15.29% had hepatitis B, 13.30% had diabetes, and 7.91% had hypertension. Our results still demonstrate that spinal tuberculosis remains a serious public health problem in Guangxi Province. Thus, preventive measures should be directed towards rural residents with comorbidities such as the elderly and diabetic.