Human infection with highly pathogenic H5N1 influenza virus

Summary Highly pathogenic H5N1 influenza A viruses have spread relentlessly across the globe since 2003, and they are associated with widespread death in poultry, substantial economic loss to farmers, and reported infections of more than 300 people with a mortality rate of 60%. The high pathogenicit...

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Published inThe Lancet (British edition) Vol. 371; no. 9622; pp. 1464 - 1475
Main Authors Gambotto, Andrea, MD, Barratt-Boyes, Simon M, PhD, de Jong, Menno D, Prof, Neumann, Gabriele, PhD, Kawaoka, Yoshihiro, Prof
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 26.04.2008
Elsevier Limited
Subjects
Animals
Antiviral Agents - therapeutic use
Avian flu
Birds
Disease transmission
Hemagglutinins - biosynthesis
Hemagglutinins - physiology
Human exposure
Humans
Influenza A Virus, H5N1 Subtype - immunology
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza A Virus, H5N1 Subtype - physiology
Influenza Vaccines
Influenza virus
Influenza, Human - mortality
Influenza, Human - physiopathology
Influenza, Human - transmission
Internal Medicine
Lymph nodes
Outbreaks
Poultry
Respiratory distress syndrome
Vaccines
Viruses
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Summary:Summary Highly pathogenic H5N1 influenza A viruses have spread relentlessly across the globe since 2003, and they are associated with widespread death in poultry, substantial economic loss to farmers, and reported infections of more than 300 people with a mortality rate of 60%. The high pathogenicity of H5N1 influenza viruses and their capacity for transmission from birds to human beings has raised worldwide concern about an impending human influenza pandemic similar to the notorious H1N1 Spanish influenza of 1918. Since many aspects of H5N1 influenza research are rapidly evolving, we aim in this Seminar to provide an up-to-date discussion on select topics of interest to influenza clinicians and researchers. We summarise the clinical features and diagnosis of infection and present therapeutic options for H5N1 infection of people. We also discuss ideas relating to virus transmission, host restriction, and pathogenesis. Finally, we discuss vaccine development in view of the probable importance of vaccination in pandemic control.
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ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(08)60627-3