Redox homeostasis in cardiac fibrosis: Focus on metal ion metabolism

• Published in: Redox biology Vol. 71; p. 103109
• Main Authors: Liu, Zhen-Yu, Liu, Zhi-Yan, Lin, Li-Chan, Song, Kai, Tu, Bin, Zhang, Ye, Yang, Jing-Jing, Zhao, Jian-Yuan, Tao, Hui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2024; Elsevier
• Subjects: Cardiac fibrosis; Extracellular matrix; Extracellular Matrix Proteins - metabolism; Fibrosis; Homeostasis; Humans; Ions; Metabolism; Metal ion; Oxidation-Reduction; Redox; Review; Metal ion; Redox; Cardiac fibrosis; Extracellular matrix; Metabolism

Cardiac fibrosis is a major public health problem worldwide, with high morbidity and mortality, affecting almost all patients with heart disease worldwide. It is characterized by fibroblast activation, abnormal proliferation, excessive deposition, and abnormal distribution of extracellular matrix (E...