Redox homeostasis in cardiac fibrosis: Focus on metal ion metabolism

• Published in: Redox biology Vol. 71; p. 103109
• Main Authors: Liu, Zhen-Yu, Liu, Zhi-Yan, Lin, Li-Chan, Song, Kai, Tu, Bin, Zhang, Ye, Yang, Jing-Jing, Zhao, Jian-Yuan, Tao, Hui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2024; Elsevier
• Subjects: Cardiac fibrosis; Extracellular matrix; Extracellular Matrix Proteins - metabolism; Fibrosis; Homeostasis; Humans; Ions; Metabolism; Metal ion; Oxidation-Reduction; Redox; Review; Metal ion; Redox; Cardiac fibrosis; Extracellular matrix; Metabolism
• ISSN: 2213-2317; 2213-2317
• DOI: 10.1016/j.redox.2024.103109

Cardiac fibrosis is a major public health problem worldwide, with high morbidity and mortality, affecting almost all patients with heart disease worldwide. It is characterized by fibroblast activation, abnormal proliferation, excessive deposition, and abnormal distribution of extracellular matrix (ECM) proteins. The maladaptive process of cardiac fibrosis is complex and often involves multiple mechanisms. With the increasing research on cardiac fibrosis, redox has been recognized as an important part of cardiac remodeling, and an imbalance in redox homeostasis can adversely affect the function and structure of the heart. The metabolism of metal ions is essential for life, and abnormal metabolism of metal ions in cells can impair a variety of biochemical processes, especially redox. However, current research on metal ion metabolism is still very limited. This review comprehensively examines the effects of metal ion (iron, copper, calcium, and zinc) metabolism-mediated redox homeostasis on cardiac fibrosis, outlines possible therapeutic interventions, and addresses ongoing challenges in this rapidly evolving field. [Display omitted] •The link between iron ions metabolism and cardiac fibrotic disease.•Iron ions metabolism play a key role in cardiac fibrosis.•Copper Ions Mediate Cell Death in Cardiac Fibrosis.•Calcium Ion Homeostasis in Cardiac Fibrosis.•Zinc Ion Homeostasis in Cardiac Fibrosis.