Unveiling myocardial microstructure shifts: exploring the impact of diabetes in stable CAD patients through CMR T1 mapping

This study investigates myocardial structural changes in stable coronary artery disease (CAD) patients with type 2 diabetes (T2D) using cardiac magnetic resonance (CMR) strain and T1 mapping. A total of 155 stable CAD patients underwent CMR examination, including left ventricular (LV) morphology and...

Full description

Saved in:
Bibliographic Details
Published inDiabetology and metabolic syndrome Vol. 16; no. 1; pp. 156 - 8
Main Authors Boros, Gustavo André Boeing, Hueb, Whady, Rezende, Paulo Cury, Rochitte, Carlos Eduardo, Nomura, Cesar Higa, Lima, Eduardo Gomes, de Oliveira Laterza Ribeiro, Matheus, Dallazen, Anderson Roberto, Garcia, Rosa Maria Rahmi, Ramires, Jose Antonio Franchini, Kalil-Filho, Roberto
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 09.07.2024
BioMed Central
BMC
Subjects
Online AccessGet full text

Cover

Loading…
More Information
Summary:This study investigates myocardial structural changes in stable coronary artery disease (CAD) patients with type 2 diabetes (T2D) using cardiac magnetic resonance (CMR) strain and T1 mapping. A total of 155 stable CAD patients underwent CMR examination, including left ventricular (LV) morphology and function assessment, late gadolinium enhancement (LGE), and feature tracking (CMR-FT) for LV global longitudinal, circumferential, and radial strain. T1 mapping with extracellular volume (ECV) evaluation was also performed. Among the enrolled patients, 67 had T2D. Diabetic patients exhibited impaired LV strain and higher ECV compared to non-diabetics. Multivariate analysis identified T2D as an independent predictor of increased ECV and decreased strain. CMR-based strain and T1 mapping highlighted impaired myocardial contractility, elevated ECV, and potential interstitial fibrosis in diabetic patients with stable CAD. This suggests a significant impact of diabetes on myocardial health beyond CAD, emphasizing the importance of a comprehensive assessment in these individuals. http://www.controlled-trials.com/ISRCTN09454308.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1758-5996
1758-5996
DOI:10.1186/s13098-024-01395-9