Unveiling myocardial microstructure shifts: exploring the impact of diabetes in stable CAD patients through CMR T1 mapping

• Published in: Diabetology and metabolic syndrome Vol. 16; no. 1; pp. 156 - 8
• Main Authors: Boros, Gustavo André Boeing, Hueb, Whady, Rezende, Paulo Cury, Rochitte, Carlos Eduardo, Nomura, Cesar Higa, Lima, Eduardo Gomes, de Oliveira Laterza Ribeiro, Matheus, Dallazen, Anderson Roberto, Garcia, Rosa Maria Rahmi, Ramires, Jose Antonio Franchini, Kalil-Filho, Roberto
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.07.2024; BioMed Central; BMC
• Subjects: Cardiac magnetic resonance - feature tracking; Cardiomyopathy; Cardiovascular disease; Clinical trials; Coronary artery disease; Coronary heart disease; Coronary vessels; Creatinine; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetics; Extracellular volume; Fibrosis; Gadolinium; Heart attacks; Heart diseases; Hyperglycemia; Ischemia; Mapping; Multivariate analysis; Muscle contraction; Regression analysis; Software; T1 mapping; Type 2 diabetes; Type 2 diabetes mellitus; Vein & artery diseases; Extracellular volume; Type 2 diabetes mellitus; Cardiac magnetic resonance - feature tracking; Coronary artery disease; T1 mapping
• ISSN: 1758-5996; 1758-5996
• DOI: 10.1186/s13098-024-01395-9

This study investigates myocardial structural changes in stable coronary artery disease (CAD) patients with type 2 diabetes (T2D) using cardiac magnetic resonance (CMR) strain and T1 mapping. A total of 155 stable CAD patients underwent CMR examination, including left ventricular (LV) morphology and function assessment, late gadolinium enhancement (LGE), and feature tracking (CMR-FT) for LV global longitudinal, circumferential, and radial strain. T1 mapping with extracellular volume (ECV) evaluation was also performed. Among the enrolled patients, 67 had T2D. Diabetic patients exhibited impaired LV strain and higher ECV compared to non-diabetics. Multivariate analysis identified T2D as an independent predictor of increased ECV and decreased strain. CMR-based strain and T1 mapping highlighted impaired myocardial contractility, elevated ECV, and potential interstitial fibrosis in diabetic patients with stable CAD. This suggests a significant impact of diabetes on myocardial health beyond CAD, emphasizing the importance of a comprehensive assessment in these individuals. http://www.controlled-trials.com/ISRCTN09454308.