Syntheses of 2-Sulfamoylmethylbenzoxazole Derivatives and Determination of Their Anticonvulsant Activities

Some 2-sulfamoylmethylbenzoxazole derivatives were synthesized from 2-bromomethylbenzoxazole by reaction with sodium bisulfite, followd by chlorination and amination. Among them, 2-sulfamoylmethylbenzoxazole (5a) showed the strongest anticonvulsant activity, which was compared with that of 3-sulfamo...

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Published inChemical & pharmaceutical bulletin Vol. 29; no. 8; pp. 2359 - 2361
Main Authors UNO, HITOSHI, KUROKAWA, MIKIO, MASUDA, YOSHINOBU
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1981
Japan Science and Technology Agency
Subjects
Animals
Anticonvulsants - chemical synthesis
Benzoxazoles - chemical synthesis
Benzoxazoles - pharmacology
Male
maximal electroshock seizure
Mice
Mice, Inbred Strains
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Summary:Some 2-sulfamoylmethylbenzoxazole derivatives were synthesized from 2-bromomethylbenzoxazole by reaction with sodium bisulfite, followd by chlorination and amination. Among them, 2-sulfamoylmethylbenzoxazole (5a) showed the strongest anticonvulsant activity, which was compared with that of 3-sulfamoylmethyl-1, 2-benzisoxazole (I).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.29.2359