Tranexamic Acid Reduces Blood Loss in Off-Pump Coronary Artery Bypass Surgery
Objective This study was designed to evaluate the hemostatic effect of tranexamic acid in off-pump coronary artery bypass surgery. Design A prospective, randomized, double-blind, placebo-controlled study. Setting The Department of Anesthesiology and Cardiac Surgery, Medical Sciences University. Part...
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Published in | Journal of cardiothoracic and vascular anesthesia Vol. 23; no. 3; pp. 312 - 315 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.06.2009
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Subjects | |
Online Access | Get full text |
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Summary: | Objective This study was designed to evaluate the hemostatic effect of tranexamic acid in off-pump coronary artery bypass surgery. Design A prospective, randomized, double-blind, placebo-controlled study. Setting The Department of Anesthesiology and Cardiac Surgery, Medical Sciences University. Participants One hundred eight patients undergoing off-pump coronary artery bypass surgery were enrolled into the study. Eight patients were withdrawn, and 100 patients were divided into 2 groups. Interventions Fifty patients received tranexamic acid (bolus 1 g before skin incision and followed by maintenance dose of 400 mg/h during surgery), and 50 patients received saline. Measurement and Main Results Hematologic parameters, volume of blood loss, blood transfusion, and other clinical data were recorded throughout the perioperative period. Twenty-four-hour postoperative blood loss was significantly less in the tranexamic acid group compared with the control group (471 ± 182 v 844 ± 303). Patients in the tranexamic acid group received significantly less allogeneic blood (8 v 31 units). Conclusion Bleeding and hemorrhagic complications and the consequent need for allogeneic transfusion are still major problems after off-pump coronary artery bypass surgery. Tranexamic acid appears to be effective in reducing postoperative bleeding and the need for allogeneic blood products. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 1053-0770 1532-8422 |
DOI: | 10.1053/j.jvca.2008.09.018 |