Type 2 Diabetes Mellitus and Cancer: Epidemiology, Physiopathology and Prevention

Individuals with type 2 diabetes mellitus are at greater risk of developing cancer and of dying from it. Both diseases are age-related, contributing to the impact of population aging on the long-term sustainability of health care systems in European Union countries. The purpose of this narrative rev...

Full description

Saved in:
Bibliographic Details
Published inBiomedicines Vol. 9; no. 10; p. 1429
Main Authors Rey-Reñones, Cristina, Baena-Díez, Jose Miguel, Aguilar-Palacio, Isabel, Miquel, Cristina, Grau, María
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 09.10.2021
MDPI
Subjects
Aging
Cancer
Cell growth
Chronic illnesses
Diabetes
Diabetes mellitus (non-insulin dependent)
Disease prevention
Epidemiology
Glucose
Growth factors
Health care
Hyperglycemia
Inflammation
Insulin
Life expectancy
Metabolism
Metastasis
Metformin
Mortality
neoplasms
obesity
Oxidative stress
Population
Review
Thiazolidinediones
Tumor necrosis factor-TNF
type 2 diabetes mellitus
Hong Kong
Online AccessGet full text

Cover

More Information
Summary:Individuals with type 2 diabetes mellitus are at greater risk of developing cancer and of dying from it. Both diseases are age-related, contributing to the impact of population aging on the long-term sustainability of health care systems in European Union countries. The purpose of this narrative review was to describe, from epidemiological, pathophysiological and preventive perspectives, the links between type 2 diabetes mellitus and the most prevalent cancers in these patients. Multiple metabolic abnormalities that may occur in type 2 diabetes mellitus, particularly obesity, could explain the increased cancer risk. In addition, the effectiveness of drugs commonly used to treat type 2 diabetes mellitus (e.g., metformin and thiazolidinediones) has been broadly evaluated in cancer prevention. Thus, a better understanding of the links between type 2 diabetes mellitus and cancer will help to identify the contributing factors and the pathophysiological pathways and to design personalized preventive strategies. The final goal is to facilitate healthy aging and the prevention of cancer and other diseases related with type 2 diabetes mellitus, which are among the main sources of disability and death in the European Union and worldwide.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines9101429