Comprehensive Clinical and Laboratory Follow-up of a Female Patient With Ebola Virus Disease: Sierra Leone Ebola Virus Persistence Study

The clinical, virologic, and immunologic findings in a female Ebola virus disease patient are described. During the long-term follow-up, Ebola virus RNA was detectable in vaginal fluid before 36 days after symptom onset, with nearly an identical genome sequence as in acute phase blood. Ebola-specifi...

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Published inOpen forum infectious diseases Vol. 6; no. 3; p. ofz068
Main Authors Liu, William J, Sesay, Foday R, Coursier, Antoine, Knust, Barbara, Marrinan, Jaclyn E, Whitmer, Shannon, McDonald, Suzanna L R, Gaillard, Philippe, Liu, Yang, Su, Qiudong, Zhang, Yong, Crozier, Ian, Ariyarajah, Archchun, Carino, Marylin, Massaquoi, Thomas, Broutet, Nathalie, Xu, Wenbo, Wu, Guizhen, Ströher, Ute, Gao, George F, Formenty, Pierre, Sahr, Foday, Deen, Gibrilla F, Bangura, James, Jambai, Amara, James, Faustine, Wurie, Alie, Yamba, Francis, Fornah, Halima, Kamara, Richard, Massaquoi, Thomas A, Davies, Tina
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 01.03.2019
Subjects
Brief Report
Ebola virus
virus genome
virus persistence
clinical sequelae
immune responses
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Summary:The clinical, virologic, and immunologic findings in a female Ebola virus disease patient are described. During the long-term follow-up, Ebola virus RNA was detectable in vaginal fluid before 36 days after symptom onset, with nearly an identical genome sequence as in acute phase blood. Ebola-specific T cells retained activation at 56 days after disease onset.
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Equal contribution, co-first authors
Equal contribution, co-last authors
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofz068