Maternal Insulin Therapy Increases Fetal Endothelial Progenitor Cells During Diabetic Pregnancy

• Published in: Diabetes care Vol. 31; no. 4; pp. 808 - 810
• Main Authors: Fadini, Gian Paolo, Baesso, Ilenia, Agostini, Carlo, Cuccato, Emily, Nardelli, Giovanni Battista, Lapolla, Annunziata, Avogaro, Angelo
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.04.2008
• Subjects: Atherosclerosis; Biological and medical sciences; Birth weight; Birth Weight - drug effects; Bone marrow; Cardiovascular disease; Complications and side effects; Development and progression; Diabetes; Diabetes in pregnancy; Diabetes therapy; Diabetes, Gestational - drug therapy; Diabetes. Impaired glucose tolerance; Diagnosis; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Endothelium, Vascular - drug effects; Endothelium, Vascular - embryology; Endothelium, Vascular - physiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Fetal Blood - cytology; Fetal Blood - drug effects; Fetus - drug effects; Fetus - physiology; Glycated Hemoglobin A - metabolism; Health aspects; Humans; Hyperglycemia; Hyperglycemia - prevention & control; Hypoglycemic Agents - therapeutic use; Infant, Newborn; Insulin; Insulin - therapeutic use; Medical sciences; Metabolic diseases; Miscellaneous; Physiological aspects; Pregnancy; Pregnancy in Diabetics - drug therapy; Pregnant women; Public health. Hygiene; Public health. Hygiene-occupational medicine; Stem Cells - cytology; Stem Cells - drug effects; Womens health; United States; Endocrinopathy; Human; Pancreatic hormone; Endothelial cell; Nutrition; Stem cell; Diabetes mellitus; Metabolic diseases; Increase; Insulin; Pregnancy; Treatment; Fetal cell; Mother; Female; Woman; Endocrinology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc07-1996

The following data about the mother were recorded: age, pregravidic BMI, weight increase, smoking habit, family history of cardiovascular disease, arterial blood pressure, and type of antidiabetic treatment. The association between maternal insulin therapy and higher fetal CD34^sup +^KDR^sup +^ cell count remained significant after correction for maternal age, hypertension, plasma glucose, family history for cardiovascular disease, cholesterol and triglyceride values, and pregravidic BMI.