Diagnostic Performance of Combined Noninvasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-MDCT: The CT Angiography and Perfusion Methods of the CORE320 Multicenter Multinational Diagnostic Study

• Published in: American journal of roentgenology (1976) Vol. 197; no. 4; pp. 829 - 837
• Main Authors: GEORGE, Richard T, ARBAB-ZADEH, Armin, LARDO, Albert C, CLOUSE, Melvin E, LIMA, Joao A. C, CERCI, Rodrigo J, VAVERE, Andrea L, KITAGAWA, Kakuya, DEWEY, Marc, ROCHITTE, Carlos E, ARAI, Andrew E, PAUL, Narinder, RYBICKI, Frank J
• Format: Journal Article
• Language: English
• Published: Reston, VA American Roentgen Ray Society 01.10.2011
• Subjects: Aged; Aged, 80 and over; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular system; Contrast Media; Coronary Angiography - methods; Coronary Disease - diagnostic imaging; Coronary heart disease; Exercise Test; Female; Heart; Humans; Image Interpretation, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Predictive Value of Tests; Prospective Studies; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiopharmaceuticals; Sensitivity and Specificity; Tomography, Emission-Computed, Single-Photon - methods; Tomography, X-Ray Computed - methods; Radionuclide study; Performance evaluation; coronary CT angiography; Angiography; Multicenter study; Cardiovascular disease; Myocardial ischemia; Myocardial disease; SPECT; Vascular disease; Atherosclerosis; myocardial CT perfusion imaging; Diagnosis; Angiocomputed tomography; Radiodiagnosis; Coronary artery; Coronary arteriography; Method; Single photon emission tomography; Coronary heart disease; Multidetector scanner; Perfusion imaging; coronary atherosclerosis; Myocardium; Medical imagery; Computerized axial tomography; Circulatory system
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/ajr.10.5689

Coronary MDCT angiography has been shown to be an accurate noninvasive tool for the diagnosis of obstructive coronary artery disease (CAD). Its sensitivity and negative predictive value for diagnosing percentage of stenosis are unsurpassed compared with those of other noninvasive testing methods. However, in its current form, it provides no information regarding the physiologic impact of CAD and is a poor predictor of myocardial ischemia. CORE320 is a multicenter multinational diagnostic study with the primary objective to evaluate the diagnostic accuracy of 320-MDCT for detecting coronary artery luminal stenosis and corresponding myocardial perfusion deficits in patients with suspected CAD compared with the reference standard of conventional coronary angiography and SPECT myocardial perfusion imaging. We aim to describe the CT acquisition, reconstruction, and analysis methods of the CORE320 study.