PD-L2 is expressed on activated human T cells and regulates their function

• Published in: Molecular immunology Vol. 48; no. 15-16; pp. 2214 - 2219
• Main Authors: Messal, Nassima, Serriari, Nacer-Eddine, Pastor, Sonia, Nunès, Jacques A., Olive, Daniel
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2011; Elsevier
• Subjects: Animals; Antigens, CD80; B7-1 Antigen - biosynthesis; B7-1 Antigen - immunology; Cell activation; Cell Separation; Costimulatory molecules; Cytokines; Cytokines - biosynthesis; Cytokines - immunology; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Immunology; Life Sciences; Lymphocyte Activation; Lymphocyte Activation - immunology; Mice; Mice, Inbred BALB C; PD-L2; Programmed Cell Death 1 Ligand 2 Protein; T cells; T-Lymphocytes; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; APCs; TcR; Cell activation; Costimulatory molecules; PD-L; PD-L2; T cells; PD-1; mAb; cell activation; costimulatory molecules

• The cosignaling molecule, PD-L2 is expressed on human activated T cell subsets. • The PD-L2 triggering down-regulates (TCR+CD28)-induced cytokine production on human T cells. • A direct targeting of PD-L2 on T cells blocks T cell proliferation. T-cell activation and proliferation are regulated by...