Polymer Controlled Drug Delivery System for Growth Hormone

The use of biomaterials as vehicles for pharmacological agents, hormones, and growth factors is at times the best treatment for controlled local administration. Our study was designed to evaluate the in vitro biocompatibility and potential clinical use of a new polymer, hydroxyethyl methacrylate-vin...

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Bibliographic Details
Published inDrug delivery Vol. 9; no. 4; pp. 233 - 237
Main Authors Gimeno, M. J., García-Esteo, F., García-Honduvilla, N., Bellón, J. M., Buján, J., Román, J. San
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.10.2002
Taylor & Francis
Subjects
Biodegradable Polymer
Controlled Release
Drug Delivery
Drug Delivery Systems - methods
Fibroblasts - drug effects
Fibroblasts - metabolism
Growth Hormone
Hema
Human Growth Hormone - administration & dosage
Human Growth Hormone - pharmacokinetics
Humans
Polymers - administration & dosage
Polymers - pharmacokinetics
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Summary:The use of biomaterials as vehicles for pharmacological agents, hormones, and growth factors is at times the best treatment for controlled local administration. Our study was designed to evaluate the in vitro biocompatibility and potential clinical use of a new polymer, hydroxyethyl methacrylate-vinyl pirrolidone. Human fibroblasts were incubated in the presence of the polymer and/or growth hormone, and evaluation was made of both the rate of polymer and hormone degradation and the proliferative effect on the fibroblast population. Results indicate that this polymer is biodegradable and lacks toxicity toward these cells. The hormone was slowly released, as suggested by enhanced cell proliferation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0049-8254
1071-7544
1366-5928
1521-0464
DOI:10.1080/10717540260397846