A Modified Method Using Static Head-Space Gas Chromatography for Determining the Stability Constants of 1-Alkanol/α-Cyclodextrin Complexation

A modification of the conventional static head-space gas chromatography method (SHSGC method) to determine stability constants for 1-alkanol/α-CD inclusion complexes was investigated. The 1 : 1 stability constants determined by this modified SHSGC method are in reasonable agreement with the correspo...

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Published inChemical & pharmaceutical bulletin Vol. 52; no. 2; pp. 259 - 261
Main Authors Misawa, Katsumasa, Hashizaki, Kaname, Taguchi, Hiroyuki, Ogawa, Naotake, Saito, Yoshihiro, Ueda, Haruhisa
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.02.2004
Subjects
1-alkanol
alpha-Cyclodextrins
Calibration
Chemical Phenomena
Chemistry, Physical
Chromatography, Gas
Cyclodextrins - chemistry
Fatty Alcohols - chemistry
modification
stability constant
static head-space gas chromatography
α-cyclodextrin
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ISSN0009-2363
1347-5223
DOI10.1248/cpb.52.259

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Summary:A modification of the conventional static head-space gas chromatography method (SHSGC method) to determine stability constants for 1-alkanol/α-CD inclusion complexes was investigated. The 1 : 1 stability constants determined by this modified SHSGC method are in reasonable agreement with the corresponding values reported previously. The modified SHSGC method precludes the necessity of the calibration curve by the use of Henry's law constant of guest. Consequently, the modified SHSGC method is more advantageous than the conventional SHSGC method because the experimental time required for determination of the stability constant is markedly reduced.
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.52.259