Titanocene-Catalyzed Coupling of Amides in the Presence of Organosilanes To Form Vicinal Diamines

A sequence of reduction, deoxygenation, and coupling steps results in a remarkable reaction, which represents an important new method for the synthesis of 1,2‐diamines. The vicinal diamines are formed by the facile coupling of aromatic amides in the presence of titanocene catalysts and PhMeSiH2 (see...

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Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 40; no. 11; pp. 2129 - 2131
Main Authors Selvakumar, Kumaravel, Harrod, John F.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 01.06.2001
WILEY‐VCH Verlag GmbH
Wiley
Subjects
amides
Chemistry
Chemistry, Multidisciplinary
diamines
homogeneous catalysis
Physical Sciences
Science & Technology
silanes
titanium
PROTOCOL
KETONES
HYDROSILATION
REDUCTION
ADDITIVES
HYDROSILYLATION
silanes
amides
homogeneous catalysis
titanium
diamines
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Summary:A sequence of reduction, deoxygenation, and coupling steps results in a remarkable reaction, which represents an important new method for the synthesis of 1,2‐diamines. The vicinal diamines are formed by the facile coupling of aromatic amides in the presence of titanocene catalysts and PhMeSiH2 (see scheme).
Bibliography:ark:/67375/WNG-9D168Z9R-R
istex:DD645D70E921611E08ACC3DE64F7B1330FDF1852
ArticleID:ANIE2129
This work was supported by the Natural Sciences and Engineering Research Council (Canada) and the Fonds FCAR du Québec.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/1521-3773(20010601)40:11<2129::AID-ANIE2129>3.0.CO;2-2