Synthetic DNA for Cell‐Surface Engineering

The cell membrane is not only a physical barrier, but also a functional organelle that regulates the communication between a cell and its environment. The ability to functionalize the cell membrane with synthetic molecules or nanostructures would advance cellular functions beyond what evolution has...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 60; no. 21; pp. 11580 - 11591
Main Authors Shi, Peng, Wang, Yong
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 17.05.2021
EditionInternational ed. in English
Subjects
Barriers
Cell interactions
Cell membranes
Cell recognition
Cell surface
cell-surface engineering
Conjugation
Deoxyribonucleic acid
DNA
Engineering
Intracellular
Microenvironments
molecular recognition
Nanostructure
Reviews
self-assembly
supramolecular structures
self-assembly
molecular recognition
cell-surface engineering
supramolecular structures
DNA
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Summary:The cell membrane is not only a physical barrier, but also a functional organelle that regulates the communication between a cell and its environment. The ability to functionalize the cell membrane with synthetic molecules or nanostructures would advance cellular functions beyond what evolution has provided. The aim of this Minireview is to introduce recent progress in using synthetic DNA and DNA‐based nanostructures for cell‐surface engineering. We first introduce chemical conjugation and physical binding methods for monovalent and polyvalent surface engineering. We then introduce the application of these methods for either the promotion or inhibition of cell–environment communication in numerous applications, including the promotion of cell–cell recognition, regulation of intracellular pathways, protection of therapeutic cells, and sensing of the intracellular and extracellular microenvironments. Lastly, we summarize current challenges existing in this area and potential solutions to solve these challenges. State‐of‐the‐art methods for using DNA to engineer cell surfaces on both a monovalent and polyvalent scale are introduced in this Minireview. The application of these methods for either the promotion or inhibition of cell–environment communication in different settings is also described.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202010278