Near‐Infrared‐II Semiconducting Polymer Dots for Deep‐tissue Fluorescence Imaging

Fluorescence imaging, particularly in the NIR‐II region (1000–1700 nm), has become an unprecedented tool for deep‐tissue in vivo imaging. Among the fluorescent nanoprobes, semiconducting polymer nanoparticles (Pdots) appear to be a promising agent because of their tunable optical and photophysical p...

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Published inChemistry, an Asian journal Vol. 16; no. 3; pp. 175 - 184
Main Authors Gupta, Nidhi, Chan, Yang‐Hsiang, Saha, Sampa, Liu, Ming‐Ho
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.02.2021
Subjects
Biocompatibility
Chemistry
deep-tissue
Fluorescence
Imaging
Nanoparticles
NIR-II
Optical properties
Particle size distribution
polymer dots
Polymers
Toxicity
NIR-II
optical properties
polymer dots
fluorescence
deep-tissue
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Summary:Fluorescence imaging, particularly in the NIR‐II region (1000–1700 nm), has become an unprecedented tool for deep‐tissue in vivo imaging. Among the fluorescent nanoprobes, semiconducting polymer nanoparticles (Pdots) appear to be a promising agent because of their tunable optical and photophysical properties, ultrahigh brightness, minimal autofluorescence, narrow‐size distribution, and low cytotoxicity. This review elucidates the recent advances in Pdots for deep‐tissue fluorescence imaging and the facing future translation to clinical use. This minireview focuses on recent developments in NIR‐II fluorescence imaging nanoprobes, particularly semiconducting Pdots for deep‐tissue bioimaging. It includes the benefits and challenges that need to be met to transform such probes into clinical practice.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202001348