Acute aortic thrombosis in the ascending aorta after cisplatin-based chemotherapy for esophageal cancer: a case report

• Published in: Surgical case reports Vol. 8; no. 1; p. 75
• Main Authors: Sato, Noriaki, Mishima, Takehito, Okubo, Yuka, Okamoto, Takeshi, Shiraishi, Shuichi, Tsuchida, Masanori
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 24.04.2022; Springer Nature B.V; SpringerOpen
• Subjects: Acute aortic thrombosis; Blood clots; Case Report; Case reports; Chemotherapy; Coronary vessels; Esophageal cancer; Medicine; Medicine & Public Health; Surgery; Thrombectomy; Thrombosis; Chemotherapy; Thrombectomy; Acute aortic thrombosis
• ISSN: 2198-7793; 2198-7793
• DOI: 10.1186/s40792-022-01431-8

Background The risk of thrombus development is considered to be increased by malignant tumors and chemotherapy. In addition, thrombosis of the ascending aorta is rare. We report a case of ascending aortic thrombectomy in a patient with esophageal cancer who developed ascending aortic thrombus after starting neoadjuvant chemotherapy, including operative findings and surgical treatment. Case presentation A 63-year-old man with esophageal cancer was administered chemotherapy comprising cisplatin plus 5-fluorouracil. A week after completing 1 cycle of chemotherapy, computed tomography angiography showed acute aortic thrombosis at the ascending aorta. The risk of embolization appeared high because the thrombosis was floating, so we performed emergency ascending aortic thrombectomy. The postoperative course was good and uncomplicated. A month after this surgery, the patient underwent surgery for esophageal cancer. As of 1 year after the cancer surgery, neither cancer nor thrombosis has recurred. Conclusion We describe a case of acute aortic thrombosis in the ascending aorta after cisplatin-based chemotherapy, that was treated by aortic thrombectomy. The treatment strategy should depend on thrombus location and the condition of the patient, but surgical treatment should be considered where possible to achieve better prognosis.