Conjugation of Porphyrin to Nanohybrid Cerasomes for Photodynamic Diagnosis and Therapy of Cancer

Shining light on cancer cells: A cerasomal photosensitizer of high stability and loading efficiency was developed by conjugation of a porphyrin molecule to an organoalkoxysilylated lipid followed by sol–gel and self‐assembly processes (see picture). This nanoformulation showed intrinsic fluorescence...

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Published inAngewandte Chemie International Edition Vol. 50; no. 49; pp. 11622 - 11627
Main Authors Liang, Xiaolong, Li, Xiaoda, Yue, Xiuli, Dai, Zhifei
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 02.12.2011
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
cancer
Chemistry
Chemistry, Multidisciplinary
HeLa Cells
Humans
Lipids - chemistry
liposomes
Liposomes - chemistry
Neoplasms - drug therapy
Phase Transition
Photochemotherapy
photodynamic therapy
Photosensitizing Agents - chemical synthesis
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Physical Sciences
Porphyrins - chemical synthesis
Porphyrins - chemistry
Porphyrins - pharmacology
Science & Technology
self-assembly
sol-gel processes
self-assembly
NANOPARTICLES
liposomes
photodynamic therapy
PHOTOSENSITIZERS
SINGLET OXYGEN
cancer
BILAYERS
sol-gel processes
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Summary:Shining light on cancer cells: A cerasomal photosensitizer of high stability and loading efficiency was developed by conjugation of a porphyrin molecule to an organoalkoxysilylated lipid followed by sol–gel and self‐assembly processes (see picture). This nanoformulation showed intrinsic fluorescence and significant damage to tumor cells under photoirradiation.
Bibliography:ark:/67375/WNG-TGJ1GZ2T-W
This research was financially supported by the National Natural Science Foundation of China (grant numbers NSFC-30970829 and 20977021).
ArticleID:ANIE201103557
National Natural Science Foundation of China - No. 30970829; No. 20977021
istex:9835D519E102BA1F3705D0CA1B777629285ECEB6
This research was financially supported by the National Natural Science Foundation of China (grant numbers NSFC‐30970829 and 20977021).
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201103557