Reconfigurable Bioinspired Framework Nucleic Acid Nanoplatform Dynamically Manipulated in Living Cells for Subcellular Imaging

• Published in: Angewandte Chemie International Edition Vol. 58; no. 6; pp. 1648 - 1653
• Main Authors: Peng, Pai, Du, Yi, Zheng, Jiao, Wang, Huihui, Li, Tao
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 04.02.2019
• Edition: International ed. in English
• Subjects: Aptamers; Assembly; Biomimetics; Cells (biology); Deoxyribonucleic acid; Dimerization; DNA; Fibers; Lysosomes; nanostructures; Nucleic acids; pH effects; Proteins; self-assembly; Silk; supramolecular chemistry; self-assembly; nucleic acids; nanostructures; supramolecular chemistry; DNA

In nature, the formation of spider silk fibers begins with dimerizing the pH‐sensitive N‐terminal domains of silk proteins (spidroins) upon lowering pH, and provides a natural masterpiece for programmable assembly. Inspired by the similarity of pH‐dependent dimerization behaviors, introduced here is...