Tumor‐targeted nano‐adjuvants to synergize photomediated immunotherapy enhanced antitumor immunity

• Published in: View (Beijing, China) Vol. 4; no. 3
• Main Authors: Zhu, Hongda, Yang, Chaobo, Yan, Aqin, Qiang, Wei, Ruan, Rui, Ma, Kai, Guan, Yeneng, Li, Jing, Yu, Qi, Zheng, Hongmei, Tu, Le, Liu, Shuang, Dai, Zhu, Sun, Yao
• Format: Journal Article
• Language: English
• Published: Beijing John Wiley & Sons, Inc 01.06.2023; Wiley
• Subjects: Adjuvants; Aluminum; Antigens; antitumor immunity; Apoptosis; Breast cancer; Cancer therapies; Chemotherapy; Cytotoxicity; Dendritic cells; Efficiency; Immune system; Immunotherapy; Laboratory animals; Lymphatic system; Metastasis; Nanoparticles; nano‐adjuvants; Particle size; Photodynamic therapy; photothermal therapy; Tumor necrosis factor-TNF; Tumors; Beijing China; United States > US; China
• ISSN: 2688-3988; 2688-268X; 2688-268X
• DOI: 10.1002/VIW.20220067

Photomediated immunotherapy explored to combine the anti‐cancer effect of phototherapy with the immune enhancement ability of immunotherapy, and shown great prospects for cancer treatment strategies. However, photomediated immunotherapy triggered antitumor immunity through the release of tumor antigens and damage‐associated molecular patterns from necrotic tumor cells was not enough mighty to improve the therapeutic benefits due to the immunosuppressive tumor microenvironments. Herein, a tumor‐targeted nano‐adjuvant Fucoidan@Al(OH)3‐Poly(I:C)/IR‐820 for tumor‐targeted therapy and metastasis inhibition was designed and prepared. The intrinsic immunomodulatory effects of tumor‐targeted nano‐adjuvant and their ability to simultaneously trigger tumor antigen release, thereby reversing immunosuppression and achieving potent antitumor immunity and augmented cancer therapy, were explored. The results proved that the multifunctional nano‐adjuvant combined with photothermal, photodynamic, and immunotherapy could effectively treat breast cancer and had metastasis inhibition effect by enhancing anti‐tumor immunity through immunomodulation, it should have great application potential in the treatment of breast cancer. The multifunctional nano‐adjuvant Fucoidan@Al(OH)3‐Poly(I:C)/IR‐820 (FAPI) combined with photothermal and photodynamic had great application potential in the treatment of breast cancer. This therapy strategy could trigger the release of tumor antigens, enhance antitumor immunity through immunomodulation and reversal of immunosuppression, thereby achieving potent antitumor immunity, inhibiting metastasis, and enhancing antitumor effects.