Photocontrollable Dynamic Micropatterning of Non-adherent Mammalian Cells Using a Photocleavable Poly(ethylene glycol) Lipid

Cells in the spotlight: A substrate was coated with a poly(ethylene glycol) (PEG) segment bound to a lipid through a linker that was cleaved by UV irradiation to leave a PEG‐coated area. Irradiation of an arbitrary pattern easily and rapidly yielded a high‐contrast cell pattern. Only the targeted ce...

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Published inAngewandte Chemie (International ed.) Vol. 51; no. 1; pp. 128 - 131
Main Authors Yamaguchi, Satoshi, Yamahira, Shinya, Kikuchi, Kyoko, Sumaru, Kimio, Kanamori, Toshiyuki, Nagamune, Teruyuki
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 02.01.2012
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Cell Adhesion
Cell Line
cell patterning
Cells, Immobilized
Humans
Lipids - chemistry
microarrays
Microfluidic Analytical Techniques
microfluids
Photolysis
Polyethylene Glycols - chemistry
Ultraviolet Rays
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Summary:Cells in the spotlight: A substrate was coated with a poly(ethylene glycol) (PEG) segment bound to a lipid through a linker that was cleaved by UV irradiation to leave a PEG‐coated area. Irradiation of an arbitrary pattern easily and rapidly yielded a high‐contrast cell pattern. Only the targeted cells on the cell pattern were selectively detached without cell damage on a microfluidic device (see picture).
Bibliography:ArticleID:ANIE201106106
istex:0B83E463BFC474E00F6FB993500FCF433B07B8D0
ark:/67375/WNG-93KR30VD-C
This work was supported by the Center for NanoBio Integration in The University of Tokyo.
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SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106106