Heteroleptic Copper(I)‐Based Complexes for Photocatalysis: Combinatorial Assembly, Discovery, and Optimization

• Published in: Angewandte Chemie International Edition Vol. 57; no. 19; pp. 5477 - 5481
• Main Authors: Minozzi, Clémentine, Caron, Antoine, Grenier‐Petel, Jean‐Christophe, Santandrea, Jeffrey, Collins, Shawn K.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 04.05.2018
• Edition: International ed. in English
• Subjects: Catalysis; Catalysts; Combinatorial analysis; Coordination compounds; Copper; copper complexes; Copper compounds; Diamines; energy transfer; Modularity; Optimization; Photocatalysis; photoredox reactions; proton-coupled electron transfer; energy transfer; photoredox reactions; copper complexes; proton-coupled electron transfer; photocatalysis
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201800144

A library of 50 copper‐based complexes derived from bisphosphines and diamines was prepared and evaluated in three mechanistically distinct photocatalytic reactions. In all cases, a copper‐based catalyst was identified to afford high yields, where new heteroleptic complexes derived from the bisphosphine BINAP displayed high efficiency across all reaction types. Importantly, the evaluation of the library of copper complexes revealed that even when photophysical data is available, it is not always possible to predict which catalyst structure will be efficient or inefficient in a given process, emphasizing the advantages for catalyst structures with high modularity and structural variability. A library of photocatalysts: Fifty copper‐based complexes derived from bisphosphines and diamines were prepared and evaluated in three mechanistically distinct photocatalytic reactions. In all cases, a copper‐based catalyst was identified to afford high yields/reactivities, emphasizing the advantages of using catalyst structures with high degrees of modularity and structural variability.