Catalytic Enantioselective Isocyanide‐Based Reactions: Beyond Passerini and Ugi Multicomponent Reactions

• Published in: Chemistry : a European journal Vol. 27; no. 22; pp. 6598 - 6619
• Main Authors: Luo, Jian, Chen, Guo‐Shu, Chen, Shu‐Jie, Li, Zhao‐Dong, Liu, Yun‐Lin
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 16.04.2021
• Subjects: [3+2] cycloaddition; cascade reactions; Catalysis; catalytic asymmetric; Chemical synthesis; Chemistry; Chemistry Techniques, Synthetic; Cyanides; Enantiomers; insertion reaction; isocyanide; Materials science; Stereoisomerism; cascade reactions; insertion reaction; [3+2] cycloaddition; catalytic asymmetric; isocyanide
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.202003224

The development of catalytic enantioselective isocyanide‐based reactions is currently of great interest because the resulting products are valuable in organic synthesis, pharmacological chemistry, and materials science. This review assembles and comprehensively summarizes the recent achievements in this rapidly growing area according to the reaction types. Special attention is paid to the advantages, limitations, possible mechanisms, and synthetic applications of each reaction. In addition, a personal outlook on the opportunities for further exploration is given at the end. Isocyanide‐based reactions: The development of catalytic enantioselective isocyanide‐based reactions is currently of great interest because the resulting products are valuable in organic synthesis, pharmacological chemistry, and materials science. This review assembles and comprehensively summarizes the recent achievements in this rapidly growing area according to the reaction types. Special attention is paid to the advantages, limitations, possible mechanisms, and synthetic applications of each reaction. In addition, a personal outlook on the opportunities for further exploration is given.