Recent Advances in the Design of Targeted Iridium(III) Photosensitizers for Photodynamic Therapy

• Published in: Chembiochem : a European journal of chemical biology Vol. 19; no. 15; pp. 1574 - 1589
• Main Authors: Huang, Huaiyi, Banerjee, Samya, Sadler, Peter J.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 06.08.2018
• Subjects: Animals; Cancer; cell imaging; cell organelles; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Coordination Complexes - therapeutic use; Drug Design; Humans; Iridium; Iridium - chemistry; Iridium - pharmacology; Iridium - therapeutic use; Irradiation; Models, Molecular; Molecular Targeted Therapy - methods; Neoplasms - drug therapy; Neoplasms - pathology; Photochemotherapy - methods; Photodynamic therapy; photosensitizers; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Photosensitizing Agents - therapeutic use; Radiation; Skin diseases; iridium; cell imaging; photosensitizers; photodynamic therapy; cell organelles
• ISSN: 1439-4227; 1439-7633; 1439-7633
• DOI: 10.1002/cbic.201800182

Photodynamic therapy (PDT) is a noninvasive treatment for certain types of cancer, bacterial, fungal and viral infections, and skin diseases. In recent years, adaptation of this treatment so as to achieve more specific targeted cancer therapy in particular has attracted significant attention. We focus herein on the design of novel iridium‐based photosensitizers (PSs) with tunable photophysical and photobiological properties as efficient PDT agents. We highlight the ability of some IrIII photosensitizers to target specific cellular components, including their activation by one‐ and two‐photon irradiation. Provoke the Ir: Photodynamic therapy (PDT) can provide noninvasive cancer treatment. We summarize and highlight recent advances in the design of efficient iridium photosensitizers targeted to mitochondria, lysosomes, endoplasmic reticulum, nucleus, and even specific cellular proteins.