Three-dimensional cardiac cine magnetic resonance imaging with an ultrasmall superparamagnetic iron oxide blood pool agent (NC100150)

• Published in: Journal of magnetic resonance imaging Vol. 11; no. 2; pp. 81 - 86
• Main Authors: Amano, Yasuo, Herfkens, Robert J., Shifrin, Roger Y., Alley, Marcus T., Pelc, Norbert J.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.02.2000
• Subjects: Adult; cardiac MRI; cardiac valves; Contrast Media - administration & dosage; Dextrans; Ferrosoferric Oxide; Heart - anatomy & histology; Humans; Image Processing, Computer-Assisted; Iron - administration & dosage; Magnetic Resonance Imaging, Cine - methods; Magnetite Nanoparticles; Male; myocardial motion; Oxides - administration & dosage; three-dimensional MRI; ultrasmall superparamagnetic iron oxide
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/(SICI)1522-2586(200002)11:2<81::AID-JMRI2>3.0.CO;2-N

The purpose of this study was to assess image quality of three‐dimensional (3D) cardiac cine magnetic resonance (MR) imaging before and after administration of a T1‐shortening ultrasmall superparamagnetic iron oxide blood pool agent (NC100150). 3D cardiac cine MR imaging was performed in 13 volunteers using a radiofrequency‐spoiled cardiac‐gated 3D cine gradient‐echo sequence with short repetition and echo times. Compared with precontrast images, postcontrast images showed no enhancement in fat and skeletal muscle, moderate enhancement in myocardium, and significant enhancement in ventricular cavity. After contrast injection, the signal ratio of the ventricular chamber to the myocardium significantly increased, and dramatic improvements were seen in the quality of the cineangiographic images and the depiction of cardiac valves. This quantitative study has shown that 3D cardiac cine MR imaging using a blood pool agent provided MR ventriculography and cineangiography with excellent image quality. J. Magn. Reson. Imaging 2000;11:81–86. © 2000 Wiley‐Liss, Inc.