Acetylcholine turnover rates in rat brain regions during cocaine self‐administration

• Published in: Journal of neurochemistry Vol. 88; no. 2; pp. 502 - 512
• Main Authors: Smith, James E., Vaughn, Tina C., Co, Conchita
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.01.2004; Blackwell
• Subjects: acetylcholine; Acetylcholine - metabolism; acetylcholine turnover rates; Animals; Biological and medical sciences; Brain - drug effects; Brain - metabolism; cholinergic; Cocaine - administration & dosage; Drug addictions; drug reinforcement; Male; Medical sciences; Neural Pathways - drug effects; Neural Pathways - metabolism; neurotransmitter turnover rates; Rats; Rats, Inbred F344; Self Administration; Toxicology; Cholinergic neuron; Rat; Toxicity; Central nervous system; drug reinforcement; Self administration; Hypothalamus; neurotransmitter turnover rates; Pallidum; Encephalon; Interneuron; Reinforcement; Cholinergic innervation; Diagonal band; Rodentia; Basal ganglion; Putamen; Vertebrata; Mammalia; Animal; acetylcholine turnover rates; cholinergic; Neurotransmitter; Acetylcholine; Cocaine; Hippocampus
• ISSN: 0022-3042; 1471-4159
• DOI: 10.1046/j.1471-4159.2003.02222.x

The involvement of cholinergic neurons in the brain processes underlying reinforcement has been recently demonstrated. This experiment assessed the potential role of cholinergic neurons in cocaine reinforcement by measuring the turnover rates of acetylcholine in brain regions of rats self‐administering cocaine and in yoked cocaine and yoked vehicle‐infused controls. The activity of cholinergic innervations of and/or interneurons in the olfactory tubercle, caudate putamen, diagonal band‐pre‐optic region, ventral pallidum, lateral and medial hypothalamus, hippocampus, ventral tegmental area and visual cortices reflected by the turnover rates of acetylcholine were significantly altered in rats self‐administering cocaine compared to yoked cocaine infused controls. These changes implicate the involvement of cholinergic neurons with cell bodies in the diagonal band‐pre‐optic region, the medial septum and several brainstem nuclei and interneurons in the caudate‐putamen and ventral pallidum in the processes underlying cocaine self‐administration. The identified cholinergic neuronal systems may have a broader role in the brain processes for natural reinforcers (i.e. food, water, etc.) since drugs of abuse are believed to produce reinforcing effects through these systems.