A randomized clinical trial to assess the effect of zinc and vitamin D supplementation in addition to hypertonic saline on treatment of acute bronchiolitis

• Published in: BMC infectious diseases Vol. 22; no. 1; p. 538
• Main Authors: Khoshnevisasl, Parisa, Sadeghzadeh, Mansour, Kamali, Koorosh, Ardalani, Armita
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.06.2022; BioMed Central; BMC
• Subjects: Age; Alfacalcidol; Bronchiolitis; Bronchiolitis - drug therapy; Bronchodilator Agents - therapeutic use; Bronchopneumonia; Calcifediol; Calciferol; Care and treatment; Child; Children & youth; Clinical trials; Cough; Cyanosis; Cyanosis - drug therapy; Diagnosis; Dietary Supplements; Disease; Double-Blind Method; Health aspects; Hospitalization; Humans; Infant; Infants; Infections; Infectious diseases; Intervention; Nebulizers and Vaporizers; Oxygen content; Passive smoking; Patients; Physiologic salines; Respiration; Respiratory rate; Respiratory Sounds; Risk factors; Saline Solution, Hypertonic - therapeutic use; Severity of Illness Index; Supplements; Testing; Treatment Outcome; Variance analysis; Viral infections; Vit D; Vitamin D; Vitamin D - therapeutic use; Wheezing; Zinc; Zinc - therapeutic use; Zinc in the body; Iran; Vit D; Infant; Supplements; Zinc; Bronchiolitis
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-022-07492-2

Bronchiolitis, the most common cause of hospitalization in infancy has not yet a definitive treatment. This study was conducted to assess the effect of Zinc and vitamin D on treatment of infants with bronchiolitis. In this double blind, randomized clinical trial, 94 infants aged 2 to 23 months, admitted in Mousavi Hospital in Zanjan, Iran, with the diagnosis of acute bronchiolitis were randomly assigned into 3 groups. The control group was only treated with hypertonic saline. The two case groups received either 100 unit/kg/day of Vitamin D or 20 mg/day of zinc in addition to hypertonic saline. Wheezing, duration of hospital stay, cough, cyanosis, respiratory distress and the respiratory rate in the first, third and seventh day of hospitalization were evaluated. There was no significant difference between groups in terms of age, sex, weight, passive smoking, wheezing, oxygen saturation, cyanosis and type of delivery. On the third day of hospitalization, the respiratory rate/min in the control group, the groups receiving vitamin D and zinc were 45.2 ± 10.7, 37.8 ± 3.9 and 41.1 ± 9.1 respectively and the result of repeated measure analysis didn't show any significant difference between the 3 groups (P = 0.562). Duration of hospitalization in the group receiving Vitamin D or zinc and in controls were 4.2 ± 2.6, 4.4 ± 2.2 and 5.1 ± 2.4 days respectively and this difference was not significant. Zinc receiving patients did not differ from the control group regarding to respiratory rate, cyanosis and wheezing. Vitamin D or zinc administration was not effective in reducing respiratory rate in children with bronchiolitis. Trial registration This project was approved by the Institutional Ethics Committee (IR, ZUMS.REC.1396.50), and registered on IRCT (IRCT20131217015835N7).