Recent Developments in Solid‐Phase Strategies towards Synthetic, Sequence‐Defined Macromolecules

Sequence‐control in synthetic polymers is an important contemporary research area because it provides the opportunity to create completely novel materials for structure–function studies. This is especially relevant for biomimetic polymers, bioactive and information security materials. The level of c...

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Bibliographic Details
Published inChemistry, an Asian journal Vol. 13; no. 23; pp. 3611 - 3622
Main Authors Hill, Stephen A., Gerke, Christoph, Hartmann, Laura
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 04.12.2018
Subjects
Biomimetic materials
Chemistry
Cybersecurity
Macromolecules
poly(amidoamines)
polymerization
Polymers
sequence-controlled polymers
sequence-defined macromolecules
solid phase
Solid phase synthesis
polymerization
sequence-defined macromolecules
solid phase
poly(amidoamines)
sequence-controlled polymers
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Summary:Sequence‐control in synthetic polymers is an important contemporary research area because it provides the opportunity to create completely novel materials for structure–function studies. This is especially relevant for biomimetic polymers, bioactive and information security materials. The level of control is strongly dependent and inherent upon the polymerization technique utilized. Today, the most established method yielding monodispersity and monomer sequence‐definition is solid‐phase synthesis. This Focus Review highlights recent advances in solid‐phase strategies to access synthetic, sequence‐defined macromolecules. Alternatives strategies towards sequence‐defined macromolecules are also briefly summarized. Everything is under control: Sequence‐control in synthetic polymers is an important contemporary research area as many novel materials can be envisaged, which is especially relevant for biomimetic and bioactive polymers, and information security materials. The level of sequential control is important and solid‐phase techniques allow methods to be developed which yield monodispersity and control of sequence‐definition. This Focus Review highlights recent advances in solid‐phase strategies to access such sequence‐defined macromolecules, while solid‐phase alternatives are also briefly summarized.
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ISSN:1861-4728
1861-471X
DOI:10.1002/asia.201801171