Bio‐Coreactant‐Enhanced Electrochemiluminescence Microscopy of Intracellular Structure and Transport

A bio‐coreactant‐enhanced electrochemiluminescence (ECL) microscopy realizes the ECL imaging of intracellular structure and dynamic transport. This microscopy uses Ru(bpy)32+ as the electrochemical molecular antenna connecting extracellular and intracellular environments, and uses intracellular biom...

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Published inAngewandte Chemie International Edition Vol. 60; no. 9; pp. 4907 - 4914
Main Authors Ma, Cheng, Wu, Shaojun, Zhou, Yang, Wei, Hui‐Fang, Zhang, Jianrong, Chen, Zixuan, Zhu, Jun‐Jie, Lin, Yuehe, Zhu, Wenlei
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 23.02.2021
EditionInternational ed. in English
Subjects
Actin
Animals
Autophagy
bioelectrochemistry
Biomolecules
Cell membranes
Cytoskeleton
Damage detection
DNA damage
DNA Damage - drug effects
Edge effect
Electrochemical Techniques
Electrochemiluminescence
Electrochemistry
Electrodes
Electroporation
HeLa Cells
Humans
Image enhancement
Image processing
Intracellular
Liver - microbiology
Liver - pathology
Luminescent Measurements
Mice
Microscopy
Microscopy, Atomic Force
Microscopy, Fluorescence - methods
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Phagocytosis
Reactive Oxygen Species - metabolism
Shewanella - isolation & purification
Single-Cell Analysis
single-cell studies
electrochemiluminescence
bioelectrochemistry
microscopy
electrochemistry
single-cell studies
Online AccessGet full text
ISSN1433-7851
1521-3773
1521-3773
DOI10.1002/anie.202012171

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Abstract A bio‐coreactant‐enhanced electrochemiluminescence (ECL) microscopy realizes the ECL imaging of intracellular structure and dynamic transport. This microscopy uses Ru(bpy)32+ as the electrochemical molecular antenna connecting extracellular and intracellular environments, and uses intracellular biomolecules as the coreactants of ECL reactions via a “catalytic route”. Accordingly, intracellular structures are identified without using multiple labels, and autophagy involving DNA oxidative damage is detected using nuclear ECL signals. A time‐resolved image sequence discloses the universal edge effect of cellular electroporation due to the influence of the geometric properties of cell membranes on the induced transmembrane voltage. The dynamic transport of Ru(bpy)33+ in the different cellular compartments unveils the heterogeneous intracellular diffusivity correlating with the actin cytoskeleton. In addition to single‐cell studies, the bio‐coreactant‐enhanced ECL microscopy is used to image a slice of a mouse liver and a colony of Shewanella oneidensis MR‐1. Amine‐rich biomolecules as consumed coreactants drive electrochemiluminescence with Ru(bpy)32+, enabling bio‐coreactant‐enhanced single‐cell electrochemiluminescence microscopy. This allows the imaging of intracellular hierarchical structures without the use of multiple labels. Dynamic signals disclose the universal edge effect of cellular electroporation and enable the visualization of heterogeneous molecular transport.
AbstractList A bio‐coreactant‐enhanced electrochemiluminescence (ECL) microscopy realizes the ECL imaging of intracellular structure and dynamic transport. This microscopy uses Ru(bpy)32+ as the electrochemical molecular antenna connecting extracellular and intracellular environments, and uses intracellular biomolecules as the coreactants of ECL reactions via a “catalytic route”. Accordingly, intracellular structures are identified without using multiple labels, and autophagy involving DNA oxidative damage is detected using nuclear ECL signals. A time‐resolved image sequence discloses the universal edge effect of cellular electroporation due to the influence of the geometric properties of cell membranes on the induced transmembrane voltage. The dynamic transport of Ru(bpy)33+ in the different cellular compartments unveils the heterogeneous intracellular diffusivity correlating with the actin cytoskeleton. In addition to single‐cell studies, the bio‐coreactant‐enhanced ECL microscopy is used to image a slice of a mouse liver and a colony of Shewanella oneidensis MR‐1. Amine‐rich biomolecules as consumed coreactants drive electrochemiluminescence with Ru(bpy)32+, enabling bio‐coreactant‐enhanced single‐cell electrochemiluminescence microscopy. This allows the imaging of intracellular hierarchical structures without the use of multiple labels. Dynamic signals disclose the universal edge effect of cellular electroporation and enable the visualization of heterogeneous molecular transport.
A bio‐coreactant‐enhanced electrochemiluminescence (ECL) microscopy realizes the ECL imaging of intracellular structure and dynamic transport. This microscopy uses Ru(bpy)32+ as the electrochemical molecular antenna connecting extracellular and intracellular environments, and uses intracellular biomolecules as the coreactants of ECL reactions via a “catalytic route”. Accordingly, intracellular structures are identified without using multiple labels, and autophagy involving DNA oxidative damage is detected using nuclear ECL signals. A time‐resolved image sequence discloses the universal edge effect of cellular electroporation due to the influence of the geometric properties of cell membranes on the induced transmembrane voltage. The dynamic transport of Ru(bpy)33+ in the different cellular compartments unveils the heterogeneous intracellular diffusivity correlating with the actin cytoskeleton. In addition to single‐cell studies, the bio‐coreactant‐enhanced ECL microscopy is used to image a slice of a mouse liver and a colony of Shewanella oneidensis MR‐1.
A bio-coreactant-enhanced electrochemiluminescence (ECL) microscopy realizes the ECL imaging of intracellular structure and dynamic transport. This microscopy uses Ru(bpy)32+ as the electrochemical molecular antenna connecting extracellular and intracellular environments, and uses intracellular biomolecules as the coreactants of ECL reactions via a "catalytic route". Accordingly, intracellular structures are identified without using multiple labels, and autophagy involving DNA oxidative damage is detected using nuclear ECL signals. A time-resolved image sequence discloses the universal edge effect of cellular electroporation due to the influence of the geometric properties of cell membranes on the induced transmembrane voltage. The dynamic transport of Ru(bpy)33+ in the different cellular compartments unveils the heterogeneous intracellular diffusivity correlating with the actin cytoskeleton. In addition to single-cell studies, the bio-coreactant-enhanced ECL microscopy is used to image a slice of a mouse liver and a colony of Shewanella oneidensis MR-1.A bio-coreactant-enhanced electrochemiluminescence (ECL) microscopy realizes the ECL imaging of intracellular structure and dynamic transport. This microscopy uses Ru(bpy)32+ as the electrochemical molecular antenna connecting extracellular and intracellular environments, and uses intracellular biomolecules as the coreactants of ECL reactions via a "catalytic route". Accordingly, intracellular structures are identified without using multiple labels, and autophagy involving DNA oxidative damage is detected using nuclear ECL signals. A time-resolved image sequence discloses the universal edge effect of cellular electroporation due to the influence of the geometric properties of cell membranes on the induced transmembrane voltage. The dynamic transport of Ru(bpy)33+ in the different cellular compartments unveils the heterogeneous intracellular diffusivity correlating with the actin cytoskeleton. In addition to single-cell studies, the bio-coreactant-enhanced ECL microscopy is used to image a slice of a mouse liver and a colony of Shewanella oneidensis MR-1.
A bio‐coreactant‐enhanced electrochemiluminescence (ECL) microscopy realizes the ECL imaging of intracellular structure and dynamic transport. This microscopy uses Ru(bpy) 3 2+ as the electrochemical molecular antenna connecting extracellular and intracellular environments, and uses intracellular biomolecules as the coreactants of ECL reactions via a “catalytic route”. Accordingly, intracellular structures are identified without using multiple labels, and autophagy involving DNA oxidative damage is detected using nuclear ECL signals. A time‐resolved image sequence discloses the universal edge effect of cellular electroporation due to the influence of the geometric properties of cell membranes on the induced transmembrane voltage. The dynamic transport of Ru(bpy) 3 3+ in the different cellular compartments unveils the heterogeneous intracellular diffusivity correlating with the actin cytoskeleton. In addition to single‐cell studies, the bio‐coreactant‐enhanced ECL microscopy is used to image a slice of a mouse liver and a colony of Shewanella oneidensis MR‐1.
A bio-coreactant-enhanced electrochemiluminescence (ECL) microscopy realizes the ECL imaging of intracellular structure and dynamic transport. This microscopy uses Ru(bpy) as the electrochemical molecular antenna connecting extracellular and intracellular environments, and uses intracellular biomolecules as the coreactants of ECL reactions via a "catalytic route". Accordingly, intracellular structures are identified without using multiple labels, and autophagy involving DNA oxidative damage is detected using nuclear ECL signals. A time-resolved image sequence discloses the universal edge effect of cellular electroporation due to the influence of the geometric properties of cell membranes on the induced transmembrane voltage. The dynamic transport of Ru(bpy) in the different cellular compartments unveils the heterogeneous intracellular diffusivity correlating with the actin cytoskeleton. In addition to single-cell studies, the bio-coreactant-enhanced ECL microscopy is used to image a slice of a mouse liver and a colony of Shewanella oneidensis MR-1.
Author Wei, Hui‐Fang
Zhu, Jun‐Jie
Ma, Cheng
Wu, Shaojun
Zhou, Yang
Zhang, Jianrong
Lin, Yuehe
Chen, Zixuan
Zhu, Wenlei
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  organization: Nanjing University
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  fullname: Wu, Shaojun
  organization: Nanjing University
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  givenname: Yang
  surname: Zhou
  fullname: Zhou, Yang
  organization: Washington State University
– sequence: 4
  givenname: Hui‐Fang
  surname: Wei
  fullname: Wei, Hui‐Fang
  organization: Nanjing University
– sequence: 5
  givenname: Jianrong
  surname: Zhang
  fullname: Zhang, Jianrong
  organization: Nanjing University
– sequence: 6
  givenname: Zixuan
  surname: Chen
  fullname: Chen, Zixuan
  email: chenzixuan@nju.edu.cn
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  surname: Lin
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  organization: Washington State University
– sequence: 9
  givenname: Wenlei
  surname: Zhu
  fullname: Zhu, Wenlei
  email: wenlei.zhu@wsu.edu
  organization: Washington State University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33188721$$D View this record in MEDLINE/PubMed
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Keywords electrochemiluminescence
bioelectrochemistry
microscopy
electrochemistry
single-cell studies
Language English
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Notes These authors contributed equally to this work.
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Snippet A bio‐coreactant‐enhanced electrochemiluminescence (ECL) microscopy realizes the ECL imaging of intracellular structure and dynamic transport. This microscopy...
A bio-coreactant-enhanced electrochemiluminescence (ECL) microscopy realizes the ECL imaging of intracellular structure and dynamic transport. This microscopy...
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SubjectTerms Actin
Animals
Autophagy
bioelectrochemistry
Biomolecules
Cell membranes
Cytoskeleton
Damage detection
DNA damage
DNA Damage - drug effects
Edge effect
Electrochemical Techniques
Electrochemiluminescence
Electrochemistry
Electrodes
Electroporation
HeLa Cells
Humans
Image enhancement
Image processing
Intracellular
Liver - microbiology
Liver - pathology
Luminescent Measurements
Mice
Microscopy
Microscopy, Atomic Force
Microscopy, Fluorescence - methods
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacology
Phagocytosis
Reactive Oxygen Species - metabolism
Shewanella - isolation & purification
Single-Cell Analysis
single-cell studies
Title Bio‐Coreactant‐Enhanced Electrochemiluminescence Microscopy of Intracellular Structure and Transport
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fanie.202012171
https://www.ncbi.nlm.nih.gov/pubmed/33188721
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