D‐dimer levels is associated with severe COVID‐19 infections: A meta‐analysis
Objective The ongoing pandemic of COVID‐19 caused by the novel coronavirus Syndrome‐Coronavirus‐2 (SARS‐CoV‐2) is an emerging, rapidly evolving situation. Excluded typical manifestation of pneumonia and acute respiratory symptoms, COVID‐19 patients also have abnormal D‐dimer concentration in the ser...
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Published in | International Journal of Clinical Practice Vol. 75; no. 8; pp. e14031 - n/a |
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Main Authors | , , , |
Format | Journal Article Web Resource |
Language | English |
Published |
England
John Wiley & Sons, Inc
01.08.2021
Hindawi Limited John Wiley and Sons Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Objective
The ongoing pandemic of COVID‐19 caused by the novel coronavirus Syndrome‐Coronavirus‐2 (SARS‐CoV‐2) is an emerging, rapidly evolving situation. Excluded typical manifestation of pneumonia and acute respiratory symptoms, COVID‐19 patients also have abnormal D‐dimer concentration in the serum, but the results are controversial.
Method
A meta‐analysis first aims to explored the connection between D‐dimer concentration and COVID‐19 patients.
Results
Our results found a significant relationship between D‐dimer and COVID‐19, with a pooled OR of 1.90 (95% CI: 1.32‐2.48; P < .001). The pooled data were calculated with the REM as a high heterogeneity within the studies. The sensitivity analysis results showed that the WMD ranged from 1.69 (95% CI: 1.15 to 2.23) to 2.06 (95% CI: 1.51 to 2.62) and there was no publication bias.
Conclusions
Our meta‐analysis showed that the severity of patients with COVID‐19 significance related to D‐dimer concentrations. Meanwhile, the severe COVID‐19 patients tend to have a higher concentration of D‐dimer when compared with non‐severe patients.
Review criteria
We used MASH word and searched the online database and followed the inclusion and exclusion standard. The detailed information can be found in the text.
Message for the clinic
Our meta‐analysis showed that the severity of patients with COVID‐19 significance related to D‐dimer concentrations. This may be helpful for the clinic COVID‐19 patients. |
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Bibliography: | Wei‐Na Du and Ying Zhang are Co‐first author SourceType-Other Sources-1 ObjectType-Article-2 content type line 63 ObjectType-Feature-1 |
ISSN: | 1368-5031 1742-1241 |
DOI: | 10.1111/ijcp.14031 |