Catalytic Asymmetric Synthesis of Isoindolinones

• Published in: Chemistry, an Asian journal Vol. 14; no. 9; pp. 1306 - 1322
• Main Authors: Gao, Wei, Chen, Mu‐wang, Ding, Qiuping, Peng, Yiyuan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 02.05.2019
• Subjects: asymmetric; Asymmetry; Catalysis; Chemical synthesis; Chemistry; chiral; Coordination compounds; Copper; isoindolinones; Modularity; Nickel; organocatalysts; Palladium; Phase transfer catalysts; Transformations; Transition metal compounds; transition metals; chiral; asymmetric; organocatalysts; isoindolinones; transition metals
• ISSN: 1861-4728; 1861-471X; 1861-471X
• DOI: 10.1002/asia.201900080

As important reactive species, isoindolinones represent a cluster of valuable building blocks for the construction of natural‐product‐like compounds. In particular, chiral isoindolinones are the key structural feature of naturally occurring bioactive molecules. During the past decade, great advances have been made in the asymmetric synthesis of isoindolinone skeleton compounds. Hence, recent progress in catalytic asymmetric synthesis of isoindolinones is reviewed here, with emphasis on chiral organocatalysis and transition metal complexes enabled transformations. Different organocatalysts (chiral phosphoric acids, phase transfer catalysts, chiral thioureas) and chiral transition‐metal complexes (Rh, Pd, Ir, Cu, Mg, and Ni) are included in this transformation. Isoindolinone synthesis: This review summarizes the asymmetric synthesis of isoindolinones, with focus on chiral organocatalysis and transition metal complexes enabled reactions. Different organocatalysts (such as chiral phosphoric acids, phase transfer catalysts, chiral thioureas) and chiral transition‐metal complexes (Rh, Pd, Ir, Cu, Mg, and Ni) are included, providing a complete picture of the exciting developments for this important transformation.