Enantioselective Carbonyl Catalysis Enabled by Chiral Aldehydes

• Published in: Angewandte Chemie International Edition Vol. 58; no. 21; pp. 6818 - 6825
• Main Authors: Wang, Qiang, Gu, Qing, You, Shu‐Li
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 20.05.2019
• Edition: International ed. in English
• Subjects: Activation; Aldehydes; Amines; asymmetric catalysis; carbonyl catalysis; Carbonyls; Catalysis; Catalysts; chiral aldehydes; Enantiomers; Mannich reaction; organocatalysis; organocatalysis; carbonyl catalysis; chiral aldehydes; asymmetric catalysis; Mannich reaction
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.201808700

Organocatalytic methods have achieved spectacular advancements for the preparation of chiral molecules in highly enantioenriched forms. The fast development of this field can mainly be attributed to the evolution of general and reliable activation modes. The discovery and identification of new activation modes are therefore highly desirable to push the boundaries of asymmetric reactions. In this Minireview, recent advances in enantioselective carbonyl catalysis, one useful subbranch of organocatalysis for the efficient activation of simple amines, will be summarized. With elegantly designed chiral aldehyde catalysts, highly enantioselective and efficient asymmetric reactions can be developed. Continued development of enantioselective carbonyl catalysis is expected in the future. Highly efficient organocatalysis: Enantioselective carbonyl catalysis has become one useful subbranch of organocatalysis and has proved to be very efficient for the activation of simple amines. In this Minireview, recent advances in enantioselective carbonyl catalysis will be discussed.