Isoxazole Functionalization Technologies Enable Construction of Tetracycline Derivatives

Reactive response: Tetracyclines are potent antimicrobial agents—however, their high consumption level has contributed to the emergence of widespread bacterial resistance, which in turn stimulates the systematic search for new tetracycline analogues. In recent years, new synthetic methods have emerg...

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Bibliographic Details
Published inAngewandte Chemie (International ed.) Vol. 50; no. 37; pp. 8474 - 8477
Main Author Heasley, Brian
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 05.09.2011
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
Anti-Bacterial Agents - chemical synthesis
antimicrobial agents
bacterial resistance
Biological Products - chemical synthesis
Heterocyclic Compounds, 4 or More Rings - chemical synthesis
isoxazole
seragakinone A
tetracycline
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Summary:Reactive response: Tetracyclines are potent antimicrobial agents—however, their high consumption level has contributed to the emergence of widespread bacterial resistance, which in turn stimulates the systematic search for new tetracycline analogues. In recent years, new synthetic methods have emerged that provide access to a broad range of tetracycline analogues.
Bibliography:ark:/67375/WNG-QMX5JR0G-V
Alan Long, Hyoung Ik Lee and Bharathi Pandi are acknowledged for enriching discussions pertaining to organic and medicinal chemistry. Graphics: Michael J. Malaska. Background photo adapted from Public Health Image Library ID no. 9994 (CDC/Janice Haney Carr).
ArticleID:ANIE201102480
istex:31A9E8CBC112A1A169C34D88FB5F099E9A48276D
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201102480