Prevalence and species distribution of Candida bloodstream infection in children and adults in two teaching university hospitals in Egypt: first report of Candida kefyr
Background Candidemia is a pervasive problem associated with significant morbidity and mortality in health care settings. This study aimed to determine the changing distribution of Candida species and the emergence of uncommon species. Methods This was a cross-sectional study performed in two Cairo...
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Published in | Infection Vol. 51; no. 2; pp. 389 - 395 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.04.2023
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Background
Candidemia is a pervasive problem associated with significant morbidity and mortality in health care settings. This study aimed to determine the changing distribution of
Candida
species and the emergence of uncommon species.
Methods
This was a cross-sectional study performed in two Cairo University hospitals between 2019 and 2020. All
Candida
species isolates recovered from blood cultures of adults and pediatrics patients admitted to the hospitals were included.
Candida
isolates were identified by chromogenic
Candida
agar and Vitek2 YST identification card.
Candida kefyr
was confirmed by chip array.
Results
Candida
species were responsible for 1.6% of bloodstream infections in adults and 10.8% in pediatric patients.
C. albicans
was the most prevalent species representing 27.8% in adults and 48.3% in pediatrics. Non-albicans species (NAC) represented the most isolated
Candida
species among adults and pediatrics (72.2% and 51.6%, respectively) with the predominance of
C. tropicalis
(27.8% and 22.5%, respectively) followed by
C. parapsilosis
(16.7% and 10.8%, respectively). The uncommon
Candida
, which is
Candida
species other than
C. albicans
,
C. parapsilosis
,
C. tropicalis
,
C. glabrata
, and
C. krusei
, represents 16.6% and 14% of all candidemia in adults and pediatrics, respectively. Only one of each of
C. lusitaniae
,
C. utilis
, and
C. kefyr
were detected in adults.
C. lusitaniae
was the most frequently recovered uncommon
Candida
among pediatrics resulting in 6.4% of candidemia followed by
C. famata
(4.3%),
C. utilis
(2.2%), and
C. kefyr
(1.1%).
Conclusions
C. albicans
is still the primary species isolated from pediatrics and adults with candidemia despite the considerable shift to the non-albicans species.
C. tropicalis
and
C. parapsilosis
are the most prevalent NAC. The increased prevalence of uncommon
Candida
species is alarming and necessitates a prompt stewardship program. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0300-8126 1439-0973 |
DOI: | 10.1007/s15010-022-01888-7 |