Comparison of Outcome in Patients With ST-Elevation Versus Non–ST-Elevation Acute Myocardial Infarction Treated With Percutaneous Coronary Intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry)

• Published in: The American journal of cardiology Vol. 100; no. 2; pp. 190 - 195
• Main Authors: Abbott, J. Dawn, MD, Ahmed, Hanna N., MD, Vlachos, Helen A., MSc, Selzer, Faith, PhD, Williams, David O., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.07.2007; Elsevier; Elsevier Limited
• Subjects: Aged; Angioplasty; Angioplasty, Balloon, Coronary; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Clinical outcomes; Comparative analysis; Coronary heart disease; Diseases of the cardiovascular system; Electrocardiography; Female; Heart; Heart attacks; Humans; Intervention; Male; Medical sciences; Myocardial Infarction - mortality; Myocardial Infarction - physiopathology; Myocardial Infarction - therapy; Myocarditis. Cardiomyopathies; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Shock, Cardiogenic - etiology; Treatment Outcome; Heart; Human; Myocardial infarction; Prognosis; Angioplasty; Acute; Lung; Coronary artery; Instrumentation therapy; Cardiovascular disease; Patient; Myocardial disease; Coronary heart disease; Phlebology; Stent; Blood; ST elevation; Dynamics; Register; Complication; Evolution; Circulatory system; Cardiology; Comparative study
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2007.02.083

Patients with ST-elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) are increasingly being treated with percutaneous coronary intervention (PCI) and we sought to determine risk of adverse outcomes by type of MI. Patients enrolled in the National Heart, Lung, and Blood Institute Dynamic Registry from 1999 to 2004 who presented with an acute MI as an indication for PCI were studied. Baseline data and in-hospital and 1-year outcomes were compared based on ST-segment elevation (STEMI, n = 903; NSTEMI, n = 583) at presentation. Patients with STEMI were younger, had fewer co-morbidities, and had less extensive coronary artery disease than did patients with NSTEMI. Angiographic success and periprocedural complications were similar by MI type. In-hospital coronary artery bypass grafting, stroke, bleeding and recurrent MI were similar but mortality was higher in patients with STEMI (4.0% vs 1.4%, p = 0.004). Cardiogenic shock was associated with the greatest risk of in-hospital death (odds ratio 26.7, 95% confidence interval 11.4 to 62.3, p = 0.0001), but STEMI was also independently predictive of mortality. At 1 year, there was no influence of MI type on outcome. Age, cardiogenic shock, renal disease, peripheral vascular disease, and cancer were predictive of death and MI. Multivessel disease and a larger number of >50% lesions were associated with the need for repeat revascularization. In conclusion, STEMI was associated with a higher likelihood of in-hospital death than was NSTEMI, but long-term outcomes after PCI were independent of MI type. At 1 year, associated co-morbidities were strongly associated with death and MI, whereas only angiographic characteristics predicted the need for repeat revascularization.